High-throughput in vitro profiling assays:: lessons learnt from experiences at Novartis

被引：24

作者：

Faller, Bernard ^{[1
]}

Wang, Jianling

Zimmerlin, Alfred

Bell, Leslie

Hamon, Jacques

Whitebread, Steven

Azzaoui, Kamal

Bojanic, Dejan

Urban, Laszlo

机构：

[1] Novartis Inst Biomed Res, Basel, Switzerland

[2] Novartis Inst Biomed Res, Cambridge, MA USA

来源：

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY | 2006年 / 2卷 / 06期

关键词：

absorption; adverse effects; drug disposition; exposure; metabolism; molecular properties;

D O I：

10.1517/17425255.2.6.823

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This article reviews the use of a selection of in vitro assays implemented at Novartis and intends to address exposure and safety in early drug discovery. The authors' own experience, based on a large number of 'real' drug discovery compounds, is described to reflect on what has worked, where improvement is needed and how to best use the data for decision making. Possible strategies are discussed, and guidelines are provided on how to organise assays, extract value and contribute knowledge from the data.

引用

页码：823 / 833

页数：11