Virus Cell-to-Cell Transmission

被引:258
作者
Mothes, Walther [1 ]
Sherer, Nathan M. [2 ]
Jin, Jing [1 ]
Zhong, Peng [1 ]
机构
[1] Yale Univ, Sch Med, Sect Microbial Pathogenesis, New Haven, CT 06536 USA
[2] Kings Coll Sch Med, Dept Infect Dis, London SE1 9RT, England
关键词
HUMAN-IMMUNODEFICIENCY-VIRUS; VIROLOGICAL SYNAPSE FORMATION; ACTIN-BASED MOTILITY; NEURONAL GROWTH CONES; IMMUNOLOGICAL SYNAPSE; DENDRITIC CELLS; VACCINIA VIRUS; IN-VIVO; ADHESION MOLECULE; HIV-INFECTION;
D O I
10.1128/JVI.00443-10
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Viral infections spread based on the ability of viruses to overcome multiple barriers and move from cell to cell, tissue to tissue, and person to person and even across species. While there are fundamental differences between these types of transmissions, it has emerged that the ability of viruses to utilize and manipulate cell-cell contact contributes to the success of viral infections. Central to the excitement in the field of virus cell-to-cell transmission is the idea that cell-to-cell spread is more than the sum of the processes of virus release and entry. This implies that virus release and entry are efficiently coordinated to sites of cell-cell contact, resulting in a process that is distinct from its individual components. In this review, we will present support for this model, illustrate the ability of viruses to utilize and manipulate cell adhesion molecules, and discuss the mechanism and driving forces of directional spreading. An understanding of viral cell-to-cell spreading will enhance our ability to intervene in the efficient spreading of viral infections.
引用
收藏
页码:8360 / 8368
页数:9
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