Alzheimer's disease - A partner for presenilin

被引：19

作者：

Schenk, D ^{[1
]}

机构：

[1] Elan Pharmaceut, S San Francisco, CA 94080 USA

来源：

NATURE | 2000年 / 407卷 / 6800期

关键词：

D O I：

10.1038/35024194

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A new protein involved in producing the amyloid-β peptide — the building block of the brain ‘plaques’ seen in Alzheimer's disease — has been identified. This discovery may provide both a new drug target and fundamental insights into how cells dispose of redundant membrane proteins.

引用

页码：34 / 35

页数：2

共 10 条

[1] A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain [J].

De Strooper, B ;

Annaert, W ;

Cupers, P ;

Saftig, P ;

Craessaerts, K ;

Mumm, JS ;

Schroeter, EH ;

Schrijvers, V ;

Wolfe, MS ;

Ray, WJ ;

Goate, A ;

Kopan, R .

NATURE, 1999, 398 (6727) :518-522

[2] Transition-state analogue inhibitors of γ-secretase bind directly to presenilin-1 [J].

Esler, WP ;

Kimberly, WT ;

Ostaszewski, BL ;

Diehl, TS ;

Moore, CL ;

Tsai, JY ;

Rahmati, T ;

Xia, WM ;

Selkoe, DJ ;

Wolfe, MS .

NATURE CELL BIOLOGY, 2000, 2 (07) :428-434

[3] Review: Neurobiology - The presenilins in Alzheimer's disease - Proteolysis holds the key [J].

Haass, C ;

De Strooper, B .

SCIENCE, 1999, 286 (5441) :916-919

[4] Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1 [J].

Li, YM ;

Xu, M ;

Lai, MT ;

Huang, Q ;

Castro, JL ;

DiMuzio-Mower, J ;

Harrison, T ;

Lellis, C ;

Nadin, JL ;

Neduvelil, JG ;

Sardana, MK ;

Shearman, MS ;

Smith, AL ;

Shi, XP ;

Yin, KC ;

Shafer, JA ;

Gardell, SJ .

NATURE, 2000, 405 (6787) :689-694

[5] Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain [J].

Schroeter, EH ;

Kisslinger, JA ;

Kopan, R .

NATURE, 1998, 393 (6683) :382-386

[6] The cell biology of β-amyloid precursor protein and presenilin in Alzheimer's disease [J].

Selkoe, DJ .

TRENDS IN CELL BIOLOGY, 1998, 8 (11) :447-453

[7] CLONING OF A GENE BEARING MISSENSE MUTATIONS IN EARLY-ONSET FAMILIAL ALZHEIMERS-DISEASE [J].

SHERRINGTON, R ;

ROGAEV, EI ;

LIANG, Y ;

ROGAEVA, EA ;

LEVESQUE, G ;

IKEDA, M ;

CHI, H ;

LIN, C ;

LI, G ;

HOLMAN, K ;

TSUDA, T ;

MAR, L ;

FONCIN, JF ;

BRUNI, AC ;

MONTESI, MP ;

SORBI, S ;

RAINERO, I ;

PINESSI, L ;

NEE, L ;

CHUMAKOV, I ;

POLLEN, D ;

BROOKES, A ;

SANSEAU, P ;

POLINSKY, RJ ;

WASCO, W ;

DASILVA, HAR ;

HAINES, JL ;

PERICAKVANCE, MA ;

TANZI, RE ;

ROSES, AD ;

FRASER, PE ;

ROMMENS, JM ;

STGEORGEHYSLOP, PH .

NATURE, 1995, 375 (6534) :754-760

[8] Function and dysfunction of the presenilins [J].

Sisodia, SS ;

Kim, SH ;

Thinakaran, G .

AMERICAN JOURNAL OF HUMAN GENETICS, 1999, 65 (01) :7-12

[9] Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity [J].

Wolfe, MS ;

Xia, WM ;

Ostaszewski, BL ;

Diehl, TS ;

Kimberly, WT ;

Selkoe, DJ .

NATURE, 1999, 398 (6727) :513-517

[10] Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing [J].

Yu, G ;

Nishimura, M ;

Arawaka, S ;

Levitan, D ;

Zhang, LL ;

Tandon, A ;

Song, YQ ;

Rogaeva, E ;

Chen, FS ;

Kawaral, T ;

Supala, A ;

Levesque, L ;

Yu, H ;

Yang, DS ;

Holmes, E ;

Millman, P ;

Liang, Y ;

Zhang, DM ;

Xu, DH ;

Sato, C ;

Rogaev, E ;

Smith, M ;

Janus, C ;

Zhang, YN ;

Aebersold, R ;

Farrer, L ;

Sorbi, S ;

Bruni, A ;

Fraser, P ;

St George-Hyslop, P .

NATURE, 2000, 407 (6800) :48-54

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