Base-excision repair of oxidative DNA damage

被引:932
作者
David, Sheila S. [1 ]
O'Shea, Valerie L.
Kundu, Sucharita
机构
[1] Univ Calif Davis, Dept Chem, 1 Shields Ave, Davis, CA 95616 USA
[2] Univ Utah, Dept Chem, Salt Lake City, UT 84112 USA
关键词
D O I
10.1038/nature05978
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Maintaining the chemical integrity of DNA in the face of assault by oxidizing agents is a constant challenge for living organisms. Base-excision repair has an important role in preventing mutations associated with a common product of oxidative damage to DNA, 8-oxoguanine. Recent structural studies have shown that 8-oxoguanine DNA glycosylases use an intricate series of steps to locate and excise 8-oxoguanine lesions efficiently against a high background of undamaged bases. The importance of preventing mutations associated with 8-oxoguanine is shown by a direct association between defects in the DNA glycosylase MUTYH and colorectal cancer. The properties of other guanine oxidation products and the associated DNA glycosylases that remove them are now also being revealed.
引用
收藏
页码:941 / 950
页数:10
相关论文
共 100 条
[1]   Spiroiminodihydantoin is a major product in the photooxidation of 2′-deoxyguanosine by the triplet states and oxyl radicals generated from hydroxyacetophenone photolysis and dioxetane thermolysis [J].
Adam, W ;
Arnold, MA ;
Grune, M ;
Nau, WM ;
Pischel, U ;
Saha-Möller, CR .
ORGANIC LETTERS, 2002, 4 (04) :537-540
[2]   Inherited variants of MYH associated with somatic G:C→T:A mutations in colorectal tumors [J].
Al-Tassan, N ;
Chmiel, NH ;
Maynard, J ;
Fleming, N ;
Livingston, AL ;
Williams, GT ;
Hodges, AK ;
Davies, DR ;
David, SS ;
Sampson, JR ;
Cheadle, JR .
NATURE GENETICS, 2002, 30 (02) :227-232
[3]  
Alhopuro Pia, 2005, Hum Mutat, V26, P393, DOI 10.1002/humu.9368
[4]   Functional characterization of human MutY homolog (hMYH) missense mutation (R231L) that is linked with hMYH-associated polyposis [J].
Bai, Haibo ;
Grist, Scott ;
Gardner, Justin ;
Suthers, Graeme ;
Wilson, Teresa M. ;
Lu, A-Lien .
CANCER LETTERS, 2007, 250 (01) :74-81
[5]   Functional characterization of two human MutY homolog (hMYH) missense mutations (R227W and V232F) that lie within the putative hMSH6 binding domain and are associated with hMYH polyposis [J].
Bai, HB ;
Jones, S ;
Guan, X ;
Wilson, TM ;
Sampson, JR ;
Cheadle, JP ;
Lu, AL .
NUCLEIC ACIDS RESEARCH, 2005, 33 (02) :597-604
[6]   A novel human DNA glycosylase that removes oxidative DNA damage and is homologous to Escherichia coli endonuclease VIII [J].
Bandaru, V ;
Sunkara, S ;
Wallace, SS ;
Bond, JP .
DNA REPAIR, 2002, 1 (07) :517-529
[7]   Structure of a DNA glycosylase searching for lesions [J].
Banerjee, A ;
Santos, WL ;
Verdine, GL .
SCIENCE, 2006, 311 (5764) :1153-1157
[8]   Structure of a repair enzyme interrogating undamaged DNA elucidates recognition of damaged DNA [J].
Banerjee, A ;
Yang, W ;
Karplus, M ;
Verdine, GL .
NATURE, 2005, 434 (7033) :612-618
[9]   A nucleobase lesion remodels the interaction of its normal neighbor in a DNA glycosylase complex [J].
Banerjee, Anirban ;
Verdline, Gregory L. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (41) :15020-15025
[10]   Repair and genetic consequences of endogenous DNA base damage in mammalian cells [J].
Barnes, DE ;
Lindahl, T .
ANNUAL REVIEW OF GENETICS, 2004, 38 :445-476