Base-excision repair of oxidative DNA damage

被引：932

作者：

David, Sheila S. ^{[1
]}

O'Shea, Valerie L.

Kundu, Sucharita

机构：

[1] Univ Calif Davis, Dept Chem, 1 Shields Ave, Davis, CA 95616 USA

[2] Univ Utah, Dept Chem, Salt Lake City, UT 84112 USA

来源：

NATURE | 2007年 / 447卷 / 7147期

关键词：

D O I：

10.1038/nature05978

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Maintaining the chemical integrity of DNA in the face of assault by oxidizing agents is a constant challenge for living organisms. Base-excision repair has an important role in preventing mutations associated with a common product of oxidative damage to DNA, 8-oxoguanine. Recent structural studies have shown that 8-oxoguanine DNA glycosylases use an intricate series of steps to locate and excise 8-oxoguanine lesions efficiently against a high background of undamaged bases. The importance of preventing mutations associated with 8-oxoguanine is shown by a direct association between defects in the DNA glycosylase MUTYH and colorectal cancer. The properties of other guanine oxidation products and the associated DNA glycosylases that remove them are now also being revealed.

引用

页码：941 / 950

页数：10

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