Autophagy-dependent viral recognition by plasmacytoid dendritic cells

被引：706

作者：

Lee, Heung Kyu

Lund, Jennifer M.

Ramanathan, Balaji

Mizushima, Noboru

Iwasaki, Akiko

机构：

[1] Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06510 USA

[2] Tokyo Med & Dent Univ, Dept Cell Physiol, Grad Sch, Tokyo, Japan

[3] Tokyo Med & Dent Univ, Dept Cell Physiol, Fac Med, Tokyo, Japan

[4] Japan Sci & Technol Agcy, Solut Oriented Res Sci & Technol, Kawaguchi, Japan

来源：

SCIENCE | 2007年 / 315卷 / 5817期

关键词：

D O I：

10.1126/science.1136880

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Plasmacytoid dendritic cells (pDCs) detect viruses in the acidified endosomes by means of Toll-like receptors (TLRs). Yet, pDC responses to certain single-stranded RNA (ssRNA) viruses occur only after live viral infection. We present evidence here that the recognition of such viruses by TLR7 requires transport of cytosolic viral replication intermediates into the lysosome by the process of autophagy. In addition, autophagy was found to be required for the production of interferon-alpha by pDCs. These results support a key role for autophagy in mediating ssRNA virus detection and interferon-alpha secretion by pDCs and suggest that cytosolic replication intermediates of viruses serve as pathogen signatures recognized by TLR7.

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页码：1398 / 1401

页数：4

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