Antiherpesvirus drugs: A promising spectrum of new drugs and drug targets

被引：125

作者：

Coen, DM ^{[1
]}

Schaffer, PA

机构：

[1] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

[2] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Med, Boston, MA 02215 USA

[3] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Microbiol & Mol Genet, Boston, MA 02215 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2003年 / 2卷 / 04期

关键词：

D O I：

10.1038/nrd1065

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In the absence of effective vaccines to control herpesvirus infections, nucleosidic antiviral drugs have been the mainstay of clinical treatment since their development in the late 1970s. However, given the drawbacks of these drugs, including the increasing emergence of drug-resistant clinical isolates, new strategies for treating herpesvirus infections are warranted. A range of promising new drugs with novel molecular targets has been developed, but will they cure latent infections?

引用

页码：278 / 288

页数：11

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