Understanding eukaryotic chemotaxis: a pseudopod-centred view

被引：111

作者：

Insall, Robert H. ^{[1
]}

机构：

[1] Beatson Inst Canc Res, Glasgow G61 1BD, Lanark, Scotland

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2010年 / 11卷 / 06期

基金：

英国医学研究理事会;

关键词：

PROTEIN BETA-SUBUNIT; CELL-MOVEMENT; DICTYOSTELIUM CHEMOTAXIS; SHALLOW GRADIENTS; LEADING-EDGE; ACTIN; SHAPE; MOTILITY; SIGNALS; ABSENCE;

D O I：

10.1038/nrm2905

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Current descriptions of eukaryotic chemotaxis and cell movement focus on how extracellular signals (chemoattractants) cause new pseudopods to form. This 'signal-centred' approach is widely accepted but is derived mostly from special cases, particularly steep chemoattractant gradients. I propose a 'pseudopod-centred' explanation, whereby most pseudopods form themselves, without needing exogenous signals, and chemoattractants only bias internal pseudopod dynamics. This reinterpretation of recent data suggests that future research should focus on pseudopod mechanics, not signal processing.

引用

页码：453 / 458

页数：6

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