Primary cold-sensitive neurons in acutely dissociated cells of rat hypothalamus

被引：12

作者：

Abe, J ^{[1
]}

Okazawa, M ^{[1
]}

Adachi, R ^{[1
]}

Matsumura, K ^{[1
]}

Kobayashi, S ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Informat, Dept Intelligence Sci & Technol, Div Biol Informat, Kyoto 6068501, Japan

来源：

NEUROSCIENCE LETTERS | 2003年 / 342卷 / 1-2期

关键词：

preoptic and anterior hypothalamus; acutely dissociated cells; cold-sensitive neuron; Ca2+ imaging; extracellular recording; torpor;

D O I：

10.1016/S0304-3940(03)00239-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Local warming or cooling of the preoptic and anterior hypothalamus (PO/AH) areas evokes various thermoregulatory responses in mammals. We have hypothesized that warm- and cold-sensitive neurons recorded in the PO/AH are multiple thermostats that regulate the core temperature against heat and cold, respectively. However, since the proportion of cold-sensitive neurons is low, it is still controversial whether primary cold-sensitive neurons exist in the PO/AH. To answer this question, we investigated cold-sensitive neurons with Ca2+ imaging in acutely dissociated PO/AH cells. Their threshold temperatures were 27.3 +/- 0.44degreesC (mean +/- SEM, n = 55). In extracellular recordings cooling evoked discharges in these cold-sensitive neurons. We conclude that primary cold-sensitive neurons with low threshold temperatures exist in PO/AH. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：29 / 32

页数：4