Antitumor activity of the immunomodulatory lead Cumaside

被引：45

作者：

Aminin, D. L. ^{[1
]}

Chaykina, E. L. ^{[1
]}

Agafonova, I. G. ^{[1
]}

Avilov, S. A. ^{[1
]}

Kalinin, V. I. ^{[1
]}

Stonik, V. A. ^{[1
]}

机构：

[1] Russian Acad Sci, Pacific Inst Bioorgan Chem, Far E Div, Vladivostok 690022, Russia

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2010年 / 10卷 / 06期

关键词：

Cumaside; Cucumariosides; Sea cucumbers; Antitumor activity; Immunomodulatory activity; TRITERPENE GLYCOSIDES; COMPOUND;

D O I：

10.1016/j.intimp.2010.03.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Anew immunomodulatory lead Cumaside that is a complex of monosulfated triterpene glycosides from the sea cucumber Cucumaria japonica and cholesterol possesses significantly less cytotoxic activity against sea urchin embryos and Ehrlich carcinoma cells than the corresponding glycosides. Nevertheless Cumaside has an antitumor activity against different forms of experimental mouse Ehrlich carcinoma in vivo both independently and in combination with cytostatics. The highest effect occurs at a treatment once a day for 7 days before the tumor inoculation followed by Cumaside treatment once a day for 7 days. Prophylactic treatment with Cumaside and subsequent therapeutic application of 5-fluorouracil suppressed the tumor growth by 43%. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：648 / 654

页数：7

共 25 条

[1] Influence of cucumariosides upon intracellular [Ca 2+]i and lysosomal activity of macrophages [J].

Agafonova, IG ;

Aminin, DL ;

Avilov, SA ;

Stonik, VA .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2003, 51 (24) :6982-6986

[2] Immunomodulatory properties of frondoside A, a major triterpene glycoside from the North Atlantic commercially harvested sea cucumber Cucumaria frondosa [J].

Aminin, D. L. ;

Agafonova, I. G. ;

Kalinin, V. I. ;

Silchenko, A. S. ;

Avilov, S. A. ;

Stonik, V. A. ;

Collin, P. D. ;

Woodward, C. .

JOURNAL OF MEDICINAL FOOD, 2008, 11 (03) :443-453

[3]

Aminin D. L., 2001, J Med Food, V4, P127, DOI 10.1089/109662001753165701

[4] The use of tritium-labeled triterpene glycosides from the holothurian Cucumaria japonica in pharmacokinetic studies [J].

Aminin D.L. ;

Shevchenko V.P. ;

Nagaev I.Yu. ;

Gladkikh R.V. ;

Kapustina I.I. ;

Likhatskaya G.N. ;

Avilov S.A. ;

Stonik V.A. .

Doklady Biological Sciences, 2008, 422 (1) :345-347

[5] Immunomodulatory properties of Cumaside [J].

Aminin, DL ;

Pinegin, BV ;

Pichugina, LV ;

Zaporozhets, TS ;

Agafonova, IG ;

Boguslavski, VM ;

Silchenko, AS ;

Avilov, SA ;

Stonik, VA .

INTERNATIONAL IMMUNOPHARMACOLOGY, 2006, 6 (07) :1070-1082

[6] Immunomodulatory effects of holothurian triterpene glycosides on mammalian splenocytes determined by mass spectrometric proteome analysis [J].

Aminin, Dmitri L. ;

Koy, Conelia ;

Dmitrenok, Pavel S. ;

Mueller-Hilke, Brigitte ;

Koczan, Dirk ;

Arbogast, Brian ;

Silchenko, Aleksandra A. ;

Kalinin, Vladimir I. ;

Avilov, Sergey A. ;

Stonik, Valentin A. ;

Collin, Peter D. ;

Thiesen, Hans-Juergen ;

Deinzer, Max L. ;

Glocker, Michael O. .

JOURNAL OF PROTEOMICS, 2009, 72 (05) :886-906

[7]

ANISIMOV M M, 1987, Biologicheskie Nauki (Moscow), P49

[8] Triterpene Glycosides from Antarctic Sea Cucumbers. 1. Structure of Liouvillosides A1, A2, A3, B1, and B2 from the Sea Cucumber Staurocucumis liouvillei: New Procedure for Separation of Highly Polar Glycoside Fractions and Taxonomic Revision [J].

Antonov, Alexandr S. ;

Avilov, Sergey A. ;

Kalinovsky, Anatoly I. ;

Anastyuk, Stanislav D. ;

Dmitrenok, Pavel S. ;

Evtushenko, Evgeny V. ;

Kalinin, Vladimir I. ;

Smirnov, Alexey V. ;

Taboada, Sergi ;

Ballesteros, Manuel ;

Avila, Conxita ;

Stonik, Valentin A. .

JOURNAL OF NATURAL PRODUCTS, 2008, 71 (10) :1677-1685

[9]

AVILOV SA, 1990, KHIM PRIRODNYK SOEDI, P787

[10] Synaptosides A and A1, triterpene glycosides from the sea cucumber Synapta maculata containing 3-O-methylglucuronic acid and their cytotoxic activity against tumor cells [J].

Avilov, Sergey A. ;

Silchenko, Alexandra S. ;

Antonov, Alexander S. ;

Kalinin, Vladimir I. ;

Kalinovsky, Anatoly I. ;

Smirnov, Alexey V. ;

Dmitrenok, Pavel S. ;

Evtushenko, Evgeny V. ;

Fedorov, Sergey N. ;

Savina, Alexandra S. ;

Shubina, Larisa K. ;

Stonik, Valentin A. .

JOURNAL OF NATURAL PRODUCTS, 2008, 71 (04) :525-531

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