An efficient synthesis of ferumoxytol induced by alternating-current magnetic field

被引：69

作者：

Chen, Bo ^{[1
]}

Li, Yang ^{[1
]}

Zhang, Xiquan ^{[2
]}

Liu, Fei ^{[2
]}

Liu, Yanlong ^{[2
]}

Ji, Min ^{[1
]}

Xiong, Fei ^{[1
]}

Gu, Ning ^{[1
]}

机构：

[1] Southeast Univ, Sch Biol Sci & Med Engn, State Key Lab Bioelect, Jiangsu Key Lab Biomat & Devices, Nanjing 210096, Jiangsu, Peoples R China

[2] Chia Tai Tianqing Pharmaceut Grp Ltd Sha, Res Inst, Xuanwu Ave 699, Nanjing 210000, Jiangsu, Peoples R China

来源：

MATERIALS LETTERS | 2016年 / 170卷

基金：

中国国家自然科学基金;

关键词：

Ferumoxytol; Alternating-current magnetic field; Magnetic materials; Nanoparticles; Chemical co-precipitation synthesis; IRON-OXIDE NANOPARTICLES; AGENT;

D O I：

10.1016/j.matlet.2016.02.006

中图分类号：

T [工业技术];

学科分类号：

120111 [工业工程];

摘要：

Ferumoxytol (Feraheme (TM)), as one kind of magnetic nanoparticles (MNPs), was approved for clinical application in USA and widely used as magnetic resonance imaging (MRI) agent in tumor and inflammation for preclinical diagnosis research. In this study, we explored a novel synthesis of ferumoxytol induced by alternating-current magnetic field (ACMF). As-prepared ferumoxytol was characterized by transmission electron microscopy (TEM), particle size analyzer, fourier transform infrared spectrometer (FT-IR), X-ray diffraction (XRD), vibrating sample magnetometer (VSM) and heating measurement in ACMF. Relative characterizations proved that as-synthesized ferumoxytol demonstrated better quality than Feraheme (TM) that was prepared by ordinary chemical co-precipitation on particle size distribution, crystallinity and magnetism. Above all, this ACMF induced synthesis may offer a better strategy for ferumoxytol preparation. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：93 / 96

页数：4

共 7 条

[1]

Emerging Applications for Ferumoxytol as a Contrast Agent in MRI [J].