An efficient stereoselective synthesis of 3-spirocyclopentene- and 3-spiropyrazole-2-oxindoles via 1,3-dipolar cycloaddition reaction

被引：98

作者：

Selvakumar, Kodirajan ^{[1
]}

Vaithiyanathan, Vadivel ^{[1
]}

Shanmugam, Ponnusamy ^{[2
]}

机构：

[1] Natl Inst Interdisciplinary Sci & Technol, Chem Sci & Technol Div, Trivandrum 695019, Kerala, India

[2] Cent Leather Res Inst, Div Organ Chem, Madras 600020, Tamil Nadu, India

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 16期

关键词：

BAYLIS-HILLMAN REACTION; MARINE-DERIVED FUNGUS; SPIROCYCLIC OXINDOLES; ALLYLIC COMPOUNDS; NATURAL-PRODUCTS; SPIRO COMPOUNDS; RING EXPANSION; CITRINADIN-A; ANNULATION; DERIVATIVES;

D O I：

10.1039/b924066g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The chemistry phosphorus and sulfur ylides have been exploited for a facile, short and efficient synthesis of 3-spirocyclopentene- and 3-spiropyrazole-2-oxindoles from E- and Z-isomers of bromo derivatives of Morita-Baylis-Hillman adducts of isatin with Ph(3)P/activated alkene/K(2)CO(3) and Me(2)S/DEAD/K(2)CO(3), respectively, via [3 + 2]-annulation strategy.

引用

页码：2826 / 2828

页数：3

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