Mesoporous Silica Microparticles Enhance the Cytotoxicity of Anticancer Platinum Drugs

被引：133

作者：

Tao, Zhimin ^{[1
]}

Toms, Bonnie ^{[2
]}

Goodisman, Jerry ^{[1
]}

Asefa, Tewodros ^{[1
]}

机构：

[1] Syracuse Univ, Dept Chem, Syracuse, NY 13244 USA

[2] SUNY Syracuse, Upstate Med Univ, Dept Pediat, Syracuse, NY 13210 USA

来源：

ACS NANO | 2010年 / 4卷 / 02期

基金：

日本学术振兴会; 美国国家科学基金会;

关键词：

mesoporous materials; nanomaterials; adsorption capacity; endocytosis; cell viability; CONTROLLED-RELEASE; CANCER-CELLS; CELLULAR RESPIRATION; NANOPARTICLES; DELIVERY; FUNCTIONALIZATION; DOXORUBICIN; CHEMOTHERAPY; INHIBITION; MOLECULES;

D O I：

10.1021/nn9015345

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report on the endocytosis and the time-dependent enhanced cytotoxicity of anticancer platinum drugs when the drugs are combined with (or loaded into) one of the two most common types of mesoporous silica materials, MCM-41 or SBA-15. The anticancer drug cisplatin and its isomer transplatin, when loaded on MCM-41 and SBA-15 microparticles, were less cytotoxic to leukemia cells than the drugs alone after 12 h exposure. However, the drug-loaded microparticles exhibited unprecedented enhanced cytotoxicity to the cancerous cells after 24 h of exposure. This cytotoxicity of the drug-loaded microparticles was even higher than of the pure drugs in solutions, suggesting that mesoporous silica microparticles loaded with cisplatin or transplatin enabled a localized intracellular release of the platinum compounds and possibly also facilitated the drug's hydrolysis, enhancing the desired cytotoxic effect.

引用

页码：789 / 794

页数：6

共 34 条

[1] INTRASTRAND CROSS-LINKS ARE NOT FORMED IN THE REACTION BETWEEN TRANSPLATIN AND NATIVE DNA - RELATION WITH THE CLINICAL INEFFICIENCY OF TRANSPLATIN [J].