Collective neuronal growth and self organization of axons

被引：7

作者：

de Gennes, P. -G. ^{[1
]}

机构：

[1] Inst Curie, Ctr Rech, F-75231 Paris 05, France

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2007年 / 104卷 / 12期

关键词：

brain formation; brain sectors; growth cones; growth fronts; signaling molecules;

D O I：

10.1073/pnas.0609871104

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

I describe an assembly of neurons that synthesizes a chemorepellant molecule and transfers this molecule to the growth cones by axonal transport. From the growth cone, the repellant diffuses in nearby regions, achieving a certain concentration profile, delta, with a gradient. The growth cone migrates preferentially toward the regions of low delta. I show that this process self-consistently generates a profile of finite width, with a relatively sharp front of neuronal growth.

引用

页码：4904 / 4906

页数：3

共 7 条

[1]

Neuronal growth:: A bistable stochastic process [J].