Public versus personal serotypes of a viral quasispecies

被引:20
作者
Hunziker, L
Ciurea, A
Recher, M
Hengartner, H
Zinkernagel, RM
机构
[1] Univ Zurich Hosp, Inst Expt Immunol, CH-8091 Zurich, Switzerland
[2] Univ Hosp Basel, Clin A, CH-4021 Basel, Switzerland
关键词
D O I
10.1073/pnas.1031671100
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Noncytopathic RNA viruses persist in their natural hosts at various levels as highly mutating quasispecies. They exhibit only one known serotype. In most inbred DBA/2 mice infected with 2 x 104 or 2 x 106 plaque-forming units (pfu) of lymphocytic choriomeningitis virus (LCMV), the virus is transiently controlled below detectable levels measured with conventional assays ( < 1.7 pfu), but reemerges despite a common neutralizing Ab (nAb) response. Wild-type virus and cloned mutant viruses that had escaped polyclonal nAb responses in vivo induced nAb titers in new hosts that were usually cross-reactive; some sera were highly specific for certain mutants. The few mice that controlled LCMV infection for > 170 days produced not only nAb against wild-type but also variably against many other mutants isolated from other mice with reemerging viremia. When DBA/2 mice were immunized and boosted with 200 pfu of a LCMV mutant, the neutralizing Ab response was limited to the immunizing "personal" clone. Thus, in contrast to classical serotype-defined cytopathic viruses (e.g., polio viruses) that induce strictly non-cross-reactive nAb titers, LCMV, a noncytopathic RNA virus, represents a dynamic multiplicity of personal serological submutants. Together, these mutants form a generally recognized "public" serotype. These findings may help to explain aspects of human infections and Ab responses against hepatitis B virus, hepatitis C virus, and HIV.
引用
收藏
页码:6015 / 6020
页数:6
相关论文
共 36 条
  • [1] RAPID DEVELOPMENT OF ISOLATE-SPECIFIC NEUTRALIZING ANTIBODIES AFTER PRIMARY HIV-1 INFECTION AND CONSEQUENT EMERGENCE OF VIRUS VARIANTS WHICH RESIST NEUTRALIZATION BY AUTOLOGOUS SERA
    ALBERT, J
    ABRAHAMSSON, B
    NAGY, K
    AURELIUS, E
    GAINES, H
    NYSTROM, G
    FENYO, EM
    [J]. AIDS, 1990, 4 (02) : 107 - 112
  • [2] ARENDRUP M, 1992, J ACQ IMMUN DEF SYND, V5, P303
  • [3] Neutralization escape in human immunodeficiency virus type 1-infected long-term nonprogressors
    Bradney, AP
    Scheer, S
    Crawford, JM
    Buchbinder, SP
    Montefiori, DC
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1999, 179 (05) : 1264 - 1267
  • [4] SIMIAN IMMUNODEFICIENCY VIRUS MUTANTS RESISTANT TO SERUM NEUTRALIZATION ARISE DURING PERSISTENT INFECTION OF RHESUS-MONKEYS
    BURNS, DPW
    COLLIGNON, C
    DESROSIERS, RC
    [J]. JOURNAL OF VIROLOGY, 1993, 67 (07) : 4104 - 4113
  • [5] VACCINE-INDUCED ESCAPE MUTANT OF HEPATITIS-B VIRUS
    CARMAN, WF
    ZANETTI, AR
    KARAYIANNIS, P
    WATERS, J
    MANZILLO, G
    TANZI, E
    ZUCKERMAN, AJ
    THOMAS, HC
    [J]. LANCET, 1990, 336 (8711) : 325 - 329
  • [6] Persistence of lymphocytic choriomeningitis virus at very low levels in immune mice
    Ciurea, A
    Klenerman, P
    Hunziker, L
    Horvath, E
    Odermatt, B
    Ochsenbein, AF
    Hengartner, H
    Zinkernagel, RM
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (21) : 11964 - 11969
  • [7] CD4+ T-cell-epitope escape mutant virus selected in vivo
    Ciurea, A
    Hunziker, L
    Martinic, MMA
    Oxenius, A
    Hengartner, H
    Zinkernagel, RM
    [J]. NATURE MEDICINE, 2001, 7 (07) : 795 - 800
  • [8] Impairment of CD4+ T cell responses during chronic virus infection prevents neutralizing antibody responses against virus escape mutants
    Ciurea, A
    Hunziker, L
    Klenerman, P
    Hengartner, H
    Zinkernagel, R
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 193 (03) : 297 - 305
  • [9] Viral persistence in vivo through selection of neutralizing antibody-escape variants
    Ciurea, A
    Klenerman, P
    Hunziker, L
    Horvath, E
    Senn, BM
    Ochsenbein, AF
    Hengartner, H
    Zinkernagel, RM
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (06) : 2749 - 2754
  • [10] DISQUISITIONS ON ORIGINAL ANTIGENIC SIN .I. EVIDENCE IN MAN
    DESTGROTH, SF
    WEBSTER, RG
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1966, 124 (03) : 331 - +