Infertility in female mice lacking the receptor for interleukin 11 is due to a defective uterine response to implantation

被引:369
作者
Robb, L [1 ]
Li, RL
Hartley, L
Nandurkar, HH
Koentgen, F
Begley, CG
机构
[1] Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
[2] Royal Melbourne Hosp, Cooperat Res Ctr Cellular Growth Factors, Parkville, Vic 3050, Australia
[3] Royal Melbourne Hosp, Bone Marrow Res Labs, Parkville, Vic 3050, Australia
关键词
D O I
10.1038/nm0398-303
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
During early pregnancy, ir! response to the implanting embryo, the surrounding uterine stroma undergoes a dramatic transformation into a specialized tissue known as the decidua. The decidua encapsulates the developing embryo, facilitating nutrient transfer and limiting trophoblast invasion. Here we show that female mice with a null mutation of the interleukin-11 receptor alpha chain are infertile because of defective decidualization. A temporal analysis revealed IL-11 expression is maximal in the normal pregnant uterus at the time of decidualization, and in situ hybridization studies showed expression of the IL-11 and the IL-ll receptor alpha chain in the developing decidual cells. These observations reveal a previously unrecognized critical role for IL-ll signaling in female reproduction.
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收藏
页码:303 / 308
页数:6
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