Genetic control of Drosophila nerve cord development

被引：200

作者：

Skeath, JB

Thor, S

机构：

[1] Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA

[2] Harvard Univ, Sch Med, Dept Neurobiol, Boston, MA 02115 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2003年 / 13卷 / 01期

基金：

美国国家卫生研究院; 美国国家科学基金会; 美国国家航空航天局;

关键词：

D O I：

10.1016/S0959-4388(03)00007-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The Drosophila ventral nerve cord has been a central model system for studying the molecular genetic mechanisms that control CNS development. Studies show that the generation of neural diversity is a multistep process initiated by the patterning and segmentation of the neuroectoderm. These events act together with the process of lateral inhibition to generate precursor cells (neuroblasts) with specific identities, distinguished by the expression of unique combinations of regulatory genes. The expression of these genes in a given neuroblast restricts the fate of its progeny, by activating specific combinations of downstream genes. These genes in turn specify the identity of any given postmitotic cell, which is evident by its cellular morphology and choice of neurotransmitter.

引用

页码：8 / 15

页数：8

共 66 条

[11]

Brody T, 2002, DEVELOPMENT, V129, P3763

[12] Binary sibling neuronal cell fate decisions in the Drosophila embryonic central nervous system are nonstochastic and require inscuteable-mediated asymmetry of ganglion mother cells [J].