Mitochondrial dysfunction in cancer

被引：253

作者：

Modica-Napolitano, JS

Singh, KK

机构：

[1] Roswell Pk Canc Inst, Dept Canc Genet, Buffalo, NY 14263 USA

[2] Merrimack Coll, Dept Biol, N Andover, MA 01845 USA

来源：

MITOCHONDRION | 2004年 / 4卷 / 5-6期

基金：

美国国家卫生研究院;

关键词：

mitochondria; cancer; mtDNA; mitochondrial dysfunction;

D O I：

10.1016/j.mito.2004.07.027

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Nearly a century of scientific research has revealed a number of notable differences in the structure and function of mitochondria between normal and cancer cells, including differences in metabolic activity, molecular composition, and mtDNA sequence. This article reviews several of these differences and discusses their clinical implications, especially with regard to the use of mitochondria as biomarkers for early detection of cancer, or as unique cellular targets for novel and selective anti-cancer agents. (C) 2004 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

引用

页码：755 / 762

页数：8

共 100 条

[1] CYTOTOXIC EFFECT OF THIACARBOCYANINE DYES ON HUMAN COLON-CARCINOMA CELLS AND INHIBITION OF BOVINE HEART MITOCHONDRIAL NADH-UBIQUINONE REDUCTASE-ACTIVITY VIA A ROTENONE-TYPE MECHANISM BY 2 OF THE DYES [J].