Role of C-Reactive Protein in Contributing to Increased Cardiovascular Risk in Metabolic Syndrome

被引:75
作者
Devaraj, Sridevi [1 ,2 ]
Valleggi, Simona [1 ,2 ]
Siegel, David [2 ]
Jialal, Ishwarlal [1 ,2 ]
机构
[1] Univ Calif Davis, Med Ctr, Lab Atherosclerosis & Metab Res, Sacramento, CA 95817 USA
[2] Vet Affairs Med Ctr, Mather, CA USA
关键词
CRP; Metabolic syndrome; Inflammation; Cardiovascular risk; CORONARY-HEART-DISEASE; ACTIVATOR INHIBITOR-1 EXPRESSION; INSULIN-RESISTANCE SYNDROME; AORTIC ENDOTHELIAL-CELLS; OXIDATIVE STRESS; MYOCARDIAL-INFARCTION; INFLAMMATORY MARKERS; BRACHIAL-ARTERY; KINASE PATHWAY; OXIDIZED LDL;
D O I
10.1007/s11883-010-0098-3
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Metabolic syndrome is associated with increased propensity for diabetes and cardiovascular disease. Low-grade inflammation is characteristic of metabolic syndrome. C-reactive protein, the best characterized biomarker of inflammation, is also an independent predictor of future cardiovascular events. This review outlines the role of high-sensitivity C-reactive protein in contributing to increased cardiovascular risk in metabolic syndrome by inducing endothelial cell dysfunction and activating monocytes.
引用
收藏
页码:110 / 118
页数:9
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