Role of C-Reactive Protein in Contributing to Increased Cardiovascular Risk in Metabolic Syndrome

被引：75

作者：

Devaraj, Sridevi ^{[1
,2
]}

Valleggi, Simona ^{[1
,2
]}

Siegel, David ^{[2
]}

Jialal, Ishwarlal ^{[1
,2
]}

机构：

[1] Univ Calif Davis, Med Ctr, Lab Atherosclerosis & Metab Res, Sacramento, CA 95817 USA

[2] Vet Affairs Med Ctr, Mather, CA USA

来源：

CURRENT ATHEROSCLEROSIS REPORTS | 2010年 / 12卷 / 02期

关键词：

CRP; Metabolic syndrome; Inflammation; Cardiovascular risk; CORONARY-HEART-DISEASE; ACTIVATOR INHIBITOR-1 EXPRESSION; INSULIN-RESISTANCE SYNDROME; AORTIC ENDOTHELIAL-CELLS; OXIDATIVE STRESS; MYOCARDIAL-INFARCTION; INFLAMMATORY MARKERS; BRACHIAL-ARTERY; KINASE PATHWAY; OXIDIZED LDL;

D O I：

10.1007/s11883-010-0098-3

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Metabolic syndrome is associated with increased propensity for diabetes and cardiovascular disease. Low-grade inflammation is characteristic of metabolic syndrome. C-reactive protein, the best characterized biomarker of inflammation, is also an independent predictor of future cardiovascular events. This review outlines the role of high-sensitivity C-reactive protein in contributing to increased cardiovascular risk in metabolic syndrome by inducing endothelial cell dysfunction and activating monocytes.

引用

页码：110 / 118

页数：9

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