Role of C-Reactive Protein in Contributing to Increased Cardiovascular Risk in Metabolic Syndrome

被引:75
作者
Devaraj, Sridevi [1 ,2 ]
Valleggi, Simona [1 ,2 ]
Siegel, David [2 ]
Jialal, Ishwarlal [1 ,2 ]
机构
[1] Univ Calif Davis, Med Ctr, Lab Atherosclerosis & Metab Res, Sacramento, CA 95817 USA
[2] Vet Affairs Med Ctr, Mather, CA USA
关键词
CRP; Metabolic syndrome; Inflammation; Cardiovascular risk; CORONARY-HEART-DISEASE; ACTIVATOR INHIBITOR-1 EXPRESSION; INSULIN-RESISTANCE SYNDROME; AORTIC ENDOTHELIAL-CELLS; OXIDATIVE STRESS; MYOCARDIAL-INFARCTION; INFLAMMATORY MARKERS; BRACHIAL-ARTERY; KINASE PATHWAY; OXIDIZED LDL;
D O I
10.1007/s11883-010-0098-3
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Metabolic syndrome is associated with increased propensity for diabetes and cardiovascular disease. Low-grade inflammation is characteristic of metabolic syndrome. C-reactive protein, the best characterized biomarker of inflammation, is also an independent predictor of future cardiovascular events. This review outlines the role of high-sensitivity C-reactive protein in contributing to increased cardiovascular risk in metabolic syndrome by inducing endothelial cell dysfunction and activating monocytes.
引用
收藏
页码:110 / 118
页数:9
相关论文
共 90 条
  • [41] C-reactive protein promotes monocyte chemoattractant protein-1-mediated chemotaxis through upregulating CC chemokine receptor 2 expression in human monocytes
    Han, KH
    Hong, KH
    Park, JH
    Ko, JS
    Kang, DH
    Choi, KJ
    Hong, MK
    Park, SW
    Park, SJ
    [J]. CIRCULATION, 2004, 109 (21) : 2566 - 2571
  • [42] Components of the "metabolic syndrome" and incidence of type 2 diabetes
    Hanson, RL
    Imperatore, G
    Bennett, PH
    Knowler, WC
    [J]. DIABETES, 2002, 51 (10) : 3120 - 3127
  • [43] The metabolic syndrome, circulating oxidized LDL, and risk of myocardial infarction in well-functioning elderly people in the health, aging, and body composition cohort
    Holvoet, P
    Kritchevsky, SB
    Tracy, RP
    Mertens, A
    Rubin, SM
    Butler, J
    Goodpaster, B
    Harris, TB
    [J]. DIABETES, 2004, 53 (04) : 1068 - 1073
  • [44] Role of endothelial dysfunction in insulin resistance
    Hsueh, WA
    Quiñones, MJ
    [J]. AMERICAN JOURNAL OF CARDIOLOGY, 2003, 92 (4A) : 10J - 17J
  • [45] Inflammatory markers in relation to insulin resistance and the metabolic syndrome
    Ingelsson, E.
    Hulthe, J.
    Lind, L.
    [J]. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2008, 38 (07) : 502 - 509
  • [46] Statin Therapy for the Metabolic Syndrome: The Evidence Base
    Jialal, Ishwarlal
    Devaraj, Sridevi
    [J]. METABOLIC SYNDROME AND RELATED DISORDERS, 2009, 7 (05) : 393 - 395
  • [47] Obesity and systemic oxidative stress - Clinical correlates of oxidative stress in the Framingham Study
    Keaney, JF
    Larson, MG
    Vasan, RS
    Wilson, PWF
    Lipinska, I
    Corey, D
    Massaro, JM
    Sutherland, P
    Vita, JA
    Benjamin, EJ
    [J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2003, 23 (03) : 434 - 439
  • [48] Interaction of oxidative stress and inflammatory response in coronary plaque instability - Important role of C-reactive protein
    Kobayashi, S
    Inoue, N
    Ohashi, Y
    Terashima, M
    Matsui, K
    Mori, T
    Fujita, H
    Awano, K
    Kobayashi, K
    Azumi, H
    Ejiri, J
    Hirata, K
    Kawashima, S
    Hayashi, Y
    Yokozaki, H
    Itoh, H
    Yokoyama, M
    [J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2003, 23 (08) : 1398 - 1404
  • [49] Prospective study of high-sensitivity C-reactive protein as a determinant of mortality: Results from the MONICA/KORA Augsburg cohort study, 1984-1998
    Koenig, Wolfgang
    Khuseyinova, Natalie
    Baumert, Jens
    Meisinger, Christa
    [J]. CLINICAL CHEMISTRY, 2008, 54 (02) : 335 - 342
  • [50] Systemic and vascular markers of inflammation in relation to metabolic syndrome and insulin resistance in adults with elevated atherosclerosis risk
    Kressel, Gaby
    Trunz, Birgit
    Bub, Achim
    Huelsmann, Olaf
    Wolters, Maike
    Lichtinghagen, Ralf
    Stichtenoth, Dirk O.
    Hahn, Andreas
    [J]. ATHEROSCLEROSIS, 2009, 202 (01) : 263 - 271