Identifying a multivariate endophenotype for substance use disorders using psychophysiological measures

被引:59
作者
Iacono, WG [1 ]
Carlson, SR [1 ]
Malone, SM [1 ]
机构
[1] Univ Minnesota, Dept Psychol, Minneapolis, MN 55455 USA
关键词
alcoholism; substance dependence; P300 event-related potential; electrodermal modulation; antisaccade eye tracking; endophenotype;
D O I
10.1016/S0167-8760(00)00132-X
中图分类号
B84 [心理学];
学科分类号
04 ; 0402 ;
摘要
This investigation examined how reduced amplitude of the P300 event-related potential (elicited from a visual oddball task) can be used together with an electrodermal response modulation measure (indexing the ability to inhibit responsivity to a temporally predictable aversive stimulus) to identify adolescents at especially high risk to develop substance dependence. One hundred and twenty-nine 17-year-old boys were divided into groups characterized as low risk (high amplitude P300 and good electrodermal modulation), high risk (reduced amplitude P300 and poor modulation), or intermediate risk (a high or good score on one measure and a low or poor score on the other). P300 amplitude and electrodermal modulation were uncorrelated. High-risk buys had 4-6 times more alcohol dependence than intermediate or low-risk buys and 2-3 times more nicotine dependence. Performance on an antisaccade eye-tracking task in which participants directed their gaze in a direction opposite to target movement was related to electrodermal modulation but not P300 amplitude. The results from all three psychophysiological measures together suggest that the neural circuits affecting P300 amplitude and electrodermal response modulation are different and that poor electrodermal response modulation may reflect an inhibitory control deficit mediated by the frontal lobes. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:81 / 96
页数:16
相关论文
共 50 条
[31]   P300 event-related potential heritability in monozygotic and dizygotic twins [J].
Katsanis, J ;
Iacono, WG ;
McGue, MK ;
Carlson, SR .
PSYCHOPHYSIOLOGY, 1997, 34 (01) :47-58
[32]  
LECKMAN JF, 1982, ARCH GEN PSYCHIAT, V39, P879
[33]   DIRECT MEASUREMENT OF SKIN CONDUCTANCE - PROPOSAL FOR STANDARDIZATION [J].
LYKKEN, DT ;
VENABLES, PH .
PSYCHOPHYSIOLOGY, 1971, 8 (05) :656-+
[34]  
MALONE SM, 2000, IN PRESS PSYCHOPHYSI
[35]   REDUCED P3 AMPLITUDES ARE ASSOCIATED WITH BOTH A FAMILY HISTORY OF ALCOHOLISM AND ANTISOCIAL PERSONALITY-DISORDER [J].
OCONNOR, S ;
BAUER, L ;
TASMAN, A ;
HESSELBROCK, V .
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 1994, 18 (08) :1307-1321
[36]   CORTICAL CONTROL OF REFLEXIVE VISUALLY-GUIDED SACCADES [J].
PIERROTDESEILLIGNY, C ;
RIVAUD, S ;
GAYMARD, B ;
AGID, Y .
BRAIN, 1991, 114 :1473-1485
[37]   P300 AND THE RISK FOR ALCOHOLISM - FAMILY HISTORY, TASK-DIFFICULTY, AND GENDER [J].
POLICH, J ;
BURNS, T ;
BLOOM, FE .
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 1988, 12 (02) :248-254
[38]   METAANALYSIS OF P300 AMPLITUDE FROM MALES AT RISK FOR ALCOHOLISM [J].
POLICH, J ;
POLLOCK, VE ;
BLOOM, FE .
PSYCHOLOGICAL BULLETIN, 1994, 115 (01) :55-73
[39]   EVENT-RELATED POTENTIALS IN INDIVIDUALS AT RISK FOR ALCOHOLISM [J].
PORJESZ, B ;
BEGLEITER, H .
ALCOHOL, 1990, 7 (05) :465-469
[40]   PREFRONTAL COGNITIVE-PROCESSES - WORKING-MEMORY AND INHIBITION IN THE ANTISACCADE TASK [J].
ROBERTS, RJ ;
HAGER, LD ;
HERON, C .
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-GENERAL, 1994, 123 (04) :374-393