In vitro activity of 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]-pyrimidine against multidrug-resistant hepatitis B virus mutants

被引：36

作者：

Brunelle, M. N.

Lucifora, J.

Neyts, J.

Villet, S.

Holy, A.

Trepo, C.

Zoulim, F.

机构：

[1] INSERM, U871, F-69003 Lyon, France

[2] Univ Lyon 1, F-69008 Lyon, France

[3] Fac Med Laennec, IFR62, F-69008 Lyon, France

[4] Katholieke Univ Leuven, Rega Inst Med Res, Louvain, Belgium

[5] Acad Sci Czech Republ, Inst Organ Chem & Biochem, Prague, Czech Republic

[6] Hop Hotel Dieu, Hospices Civils, F-69002 Lyon, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 06期

关键词：

D O I：

10.1128/AAC.01440-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The susceptibilities of drug-resistant hepatitis B virus (HBV) mutants to lamivudine, adefovir, tenofovir, entecavir, and 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]-pyrimidine (PMEO-DAPym), a novel acyclic pyrimidine analogue, were assessed in vitro. Most drug-resistant mutants, including multidrug-resistant strains, remained sensitive to tenofovir and PMEO-DAPym. Therefore, the latter molecule deserves further evaluation for the treatment of HBV infection.

引用

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页码：2240 / 2243

页数：4

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