Structure and regional distribution of nociceptin/orphanin FQ precursor

被引：139

作者：

Houtani, T

Nishi, M

Takeshima, H

Nukada, T

Sugimoto, T

机构：

[1] KANSAI MED UNIV,DEPT ANAT,MORIGUCHI,OSAKA 570,JAPAN

[2] TOKYO INST PSYCHIAT,DEPT NEUROCHEM,SETAGAYA KU,TOKYO 156,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1996年 / 219卷 / 03期

关键词：

D O I：

10.1006/bbrc.1996.0300

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have cloned cDNA carrying the entire coding sequence of the precursor protein for nociceptin/orphanin FQ, a neuropeptide-ligand for an opioid-receptor like G-protein coupled receptor. The deduced nociceptin/orphanin FQ precursor shows sequence similarity to the opioid peptide precursors and shares characteristic structural features particularly with preprodynorphin. In situ hybridization analysis of nociceptin precursor mRNA in the mouse central nervous system revealed that it is highly expressed in discrete neuronal sites with the pattern distinct from those of opioid peptides. (C) 1996 Academic Press, Inc.

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收藏

页码：714 / 719

页数：6

相关论文

共 22 条

[1] TRANSFER OF PROTEINS ACROSS MEMBRANES .2. RECONSTITUTION OF FUNCTIONAL ROUGH MICROSOMES FROM HETEROLOGOUS COMPONENTS [J].

BLOBEL, G ;

DOBBERSTEIN, B .

JOURNAL OF CELL BIOLOGY, 1975, 67 (03) :852-862

[2] MOLECULAR-CLONING AND TISSUE DISTRIBUTION OF A PUTATIVE MEMBER OF THE RAT OPIOID RECEPTOR GENE FAMILY THAT IS NOT A MU-OPIOID, DELTA-OPIOID OR KAPPA-OPIOID RECEPTOR-TYPE [J].

BUNZOW, JR ;

SAEZ, C ;

MORTRUD, M ;

BOUVIER, C ;

WILLIAMS, JT ;

LOW, M ;

GRANDY, DK .

FEBS LETTERS, 1994, 347 (2-3) :284-288

[3] MOLECULAR-CLONING, TISSUE DISTRIBUTION AND CHROMOSOMAL LOCALIZATION OF A NOVEL MEMBER OF THE OPIOID RECEPTOR GENE FAMILY [J].

CHEN, Y ;

FAN, Y ;

LIU, J ;

MESTEK, A ;

TIAN, MT ;

KOZAK, CA ;

YU, L .

FEBS LETTERS, 1994, 347 (2-3) :279-283

[4] DISTRIBUTION OF DYNORPHIN AND ENKEPHALIN PEPTIDES IN THE RAT-BRAIN [J].

FALLON, JH ;

LESLIE, FM .

JOURNAL OF COMPARATIVE NEUROLOGY, 1986, 249 (03) :293-336

[5] A TECHNIQUE FOR RADIOLABELING DNA RESTRICTION ENDONUCLEASE FRAGMENTS TO HIGH SPECIFIC ACTIVITY [J].

FEINBERG, AP ;

VOGELSTEIN, B .

ANALYTICAL BIOCHEMISTRY, 1983, 132 (01) :6-13

[6] CDNA CLONING AND REGIONAL DISTRIBUTION OF A NOVEL MEMBER OF THE OPIOID RECEPTOR FAMILY [J].

FUKUDA, K ;

KATO, S ;

MORI, K ;

NISHI, M ;

TAKESHIMA, H ;

IWABE, N ;

MIYATA, T ;

HOUTANI, T ;

SUGIMOTO, T .

FEBS LETTERS, 1994, 343 (01) :42-46

[7] FUNCTIONAL-ROLE AND SEQUENCE-ANALYSIS OF A LYMPHOCYTE ORPHAN OPIOID RECEPTOR [J].

HALFORD, WP ;

GEBHARDT, BM ;

CARR, DJJ .

JOURNAL OF NEUROIMMUNOLOGY, 1995, 59 (1-2) :91-101

[8] ISOLATION AND STRUCTURAL ORGANIZATION OF THE HUMAN PREPROENKEPHALIN-B GENE [J].

HORIKAWA, S ;

TAKAI, T ;

TOYOSATO, M ;

TAKAHASHI, H ;

NODA, M ;

KAKIDANI, H ;

KUBO, T ;

HIROSE, T ;

INAYAMA, S ;

HAYASHIDA, H ;

MIYATA, T ;

NUMA, S .

NATURE, 1983, 306 (5943) :611-614

[9] MU-OPIOID RECEPTOR - EXPRESSION AND VAGOTOMY-INDUCED DEPLETION OF THE MESSENGER-RNA IN MEDULLARY PREGANGLIONIC NEURONS [J].

HOUTANI, T ;

UEYAMA, T ;

TAKESHIMA, H ;

KATO, S ;

FUKUDA, K ;

MORI, K ;

SUGIMOTO, T .

MOLECULAR BRAIN RESEARCH, 1994, 24 (1-4) :347-352

[10] COMPILATION AND ANALYSIS OF SEQUENCES UPSTREAM FROM THE TRANSLATIONAL START SITE IN EUKARYOTIC MESSENGER-RNAS [J].

KOZAK, M .

NUCLEIC ACIDS RESEARCH, 1984, 12 (02) :857-872