MU-OPIOID RECEPTOR - EXPRESSION AND VAGOTOMY-INDUCED DEPLETION OF THE MESSENGER-RNA IN MEDULLARY PREGANGLIONIC NEURONS

被引：9

作者：

HOUTANI, T

UEYAMA, T

TAKESHIMA, H

KATO, S

FUKUDA, K

MORI, K

SUGIMOTO, T

机构：

[1] KANSAI MED UNIV,DEPT ANAT,MORIGUCHI,OSAKA 570,JAPAN

[2] INT INST ADV STUDIES,KYOTO 604,JAPAN

[3] KYOTO UNIV HOSP,DEPT ANESTHESIA,KYOTO 60601,JAPAN

来源：

MOLECULAR BRAIN RESEARCH | 1994年 / 24卷 / 1-4期

关键词：

MU OPIOID RECEPTOR; VAGAL PREGANGLIONIC NEURON; VAGOTOMY; IN SITU HYBRIDIZATION; RAT;

D O I：

10.1016/0169-328X(94)90149-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

By in situ hybridization with digoxigenin-labeled RNA probes, distinct expression of mu opioid receptor mRNA was found in rat medullary preganglionic neurons for vagal parasympathetic outflow. Two days or more following unilateral vagotomy, the expression was almost completely abolished on the operated side. The results, taken together with previous findings indicating proximodistal axonal transport of radioligand-labeled opioid receptors, suggest that the medullary preganglionic neurons thus identified are the source for mu opioid receptor acting in cardiorespiratory and gastrointestinal tissues.

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收藏

页码：347 / 352

页数：6

相关论文

共 26 条

[1] PRESYNAPTIC LOCALIZATION OF OPIATE RECEPTORS IN VAGAL AND ACCESSORY OPTIC SYSTEMS - AUTORADIOGRAPHIC STUDY [J].

ATWEH, SF ;

MURRIN, LC ;

KUHAR, MJ .

NEUROPHARMACOLOGY, 1978, 17 (01) :65-71

[2] AUTORADIOGRAPHIC LOCALIZATION OF OPIATE RECEPTORS IN RAT-BRAIN .1. SPINAL-CORD AND LOWER MEDULLA [J].

ATWEH, SF ;

KUHAR, MJ .

BRAIN RESEARCH, 1977, 124 (01) :53-67

[3] VISCEROTOPIC REPRESENTATION OF THE UPPER ALIMENTARY-TRACT IN THE MEDULLA-OBLONGATA IN THE RAT - THE NUCLEUS AMBIGUUS [J].

BIEGER, D ;

HOPKINS, DA .

JOURNAL OF COMPARATIVE NEUROLOGY, 1987, 262 (04) :546-562

[4] REGIONAL EXPRESSION AND CHROMOSOMAL LOCALIZATION OF THE DELTA-OPIATE RECEPTOR GENE [J].

BZDEGA, T ;

CHIN, HM ;

KIM, H ;

JUNG, HH ;

KOZAK, CA ;

KLEE, WA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (20) :9305-9309

[5]

CHEN Y, 1993, MOL PHARMACOL, V44, P8

[6] COMPARATIVE LOCALIZATION OF MESSENGER-RNAS ENCODING 2 FORMS OF GLUTAMIC-ACID DECARBOXYLASE WITH NONRADIOACTIVE INSITU HYBRIDIZATION METHODS [J].

ESCLAPEZ, M ;

TILLAKARATNE, NJK ;

TOBIN, AJ ;

HOUSER, CR .

JOURNAL OF COMPARATIVE NEUROLOGY, 1993, 331 (03) :339-362

[7] CLONING OF A DELTA OPIOID RECEPTOR BY FUNCTIONAL EXPRESSION [J].

EVANS, CJ ;

KEITH, DE ;

MORRISON, H ;

MAGENDZO, K ;

EDWARDS, RH .

SCIENCE, 1992, 258 (5090) :1952-1955

[8] ENDORPHIN - PARASYMPATHETIC INTERACTION IN SPINAL SHOCK [J].

FADEN, AI ;

JACOBS, TP ;

HOLADAY, JW .

JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM, 1980, 2 (03) :295-304

[9] PRIMARY STRUCTURES AND EXPRESSION FROM CDNAS OF RAT OPIOID RECEPTOR DELTA-SUBTYPES AND MU-SUBTYPES [J].

FUKUDA, K ;

KATO, S ;

MORI, K ;

NISHI, M ;

TAKESHIMA, H .

FEBS LETTERS, 1993, 327 (03) :311-314

[10] DIFFERENTIATION OF DELTA AND MU OPIATE RECEPTOR LOCALIZATIONS BY LIGHT MICROSCOPIC AUTORADIOGRAPHY [J].

GOODMAN, RR ;

SNYDER, SH ;

KUHAR, MJ ;

YOUNG, WS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (10) :6239-6243