MU-OPIOID RECEPTOR - EXPRESSION AND VAGOTOMY-INDUCED DEPLETION OF THE MESSENGER-RNA IN MEDULLARY PREGANGLIONIC NEURONS

被引：9

作者：

HOUTANI, T

UEYAMA, T

TAKESHIMA, H

KATO, S

FUKUDA, K

MORI, K

SUGIMOTO, T

机构：

[1] KANSAI MED UNIV,DEPT ANAT,MORIGUCHI,OSAKA 570,JAPAN

[2] INT INST ADV STUDIES,KYOTO 604,JAPAN

[3] KYOTO UNIV HOSP,DEPT ANESTHESIA,KYOTO 60601,JAPAN

来源：

MOLECULAR BRAIN RESEARCH | 1994年 / 24卷 / 1-4期

关键词：

MU OPIOID RECEPTOR; VAGAL PREGANGLIONIC NEURON; VAGOTOMY; IN SITU HYBRIDIZATION; RAT;

D O I：

10.1016/0169-328X(94)90149-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

By in situ hybridization with digoxigenin-labeled RNA probes, distinct expression of mu opioid receptor mRNA was found in rat medullary preganglionic neurons for vagal parasympathetic outflow. Two days or more following unilateral vagotomy, the expression was almost completely abolished on the operated side. The results, taken together with previous findings indicating proximodistal axonal transport of radioligand-labeled opioid receptors, suggest that the medullary preganglionic neurons thus identified are the source for mu opioid receptor acting in cardiorespiratory and gastrointestinal tissues.

引用

收藏

页码：347 / 352

页数：6

相关论文

共 26 条

[11] DIFFERENTIAL CARDIOVASCULAR EFFECTS MEDIATED BY MU AND KAPPA OPIATE RECEPTORS IN HINDBRAIN NUCLEI [J].

HASSEN, AH ;

FEUERSTEIN, G ;

FADEN, AI .

PEPTIDES, 1983, 4 (05) :621-625

[12] DELTA-RECEPTORS VERSUS MU-RECEPTORS - CARDIOVASCULAR AND RESPIRATORY EFFECTS OF OPIATE AGONISTS MICRO-INJECTED INTO NUCLEUS TRACTUS SOLITARIUS OF CATS [J].

HASSEN, AH ;

FEUERSTEIN, G ;

PFEIFFER, A ;

FADEN, AI .

REGULATORY PEPTIDES, 1982, 4 (06) :299-309

[13] SELECTIVE CARDIORESPIRATORY EFFECTS MEDIATED BY MU-OPIOID RECEPTORS IN THE NUCLEUS AMBIGUUS [J].

HASSEN, AH ;

FEUERSTEIN, G ;

FADEN, AI .

NEUROPHARMACOLOGY, 1984, 23 (04) :407-415

[14] CARDIOVASCULAR EFFECTS OF ENDOGENOUS OPIATE SYSTEMS [J].

HOLADAY, JW .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1983, 23 :541-594

[15] DISTRIBUTION AND CEREBELLAR PROJECTIONS OF CHOLINERGIC AND CORTICOTROPIN-RELEASING FACTOR-CONTAINING NEURONS IN THE CAUDAL VESTIBULAR NUCLEAR-COMPLEX AND ADJACENT BRAIN-STEM STRUCTURES [J].

IKEDA, M ;

HOUTANI, T ;

UEYAMA, T ;

SUGIMOTO, T .

NEUROSCIENCE, 1992, 49 (03) :635-651

[16] THE DELTA-OPIOID RECEPTOR - ISOLATION OF A CDNA BY EXPRESSION CLONING AND PHARMACOLOGICAL CHARACTERIZATION [J].

KIEFFER, BL ;

BEFORT, K ;

GAVERIAUXRUFF, C ;

HIRTH, CG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (24) :12048-12052

[17]

KONG HY, 1993, J BIOL CHEM, V268, P23055

[18] CLONING AND PHARMACOLOGICAL CHARACTERIZATION OF A RAT KAPPA-OPIOID RECEPTOR [J].

MENG, F ;

XIE, GX ;

THOMPSON, RC ;

MANSOUR, A ;

GOLDSTEIN, A ;

WATSON, SJ ;

AKIL, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (21) :9954-9958

[19] IN-SITU HYBRIDIZATION STUDY OF KAPPA-OPIOID RECEPTOR MESSENGER-RNA IN THE RAT-BRAIN [J].

MINAMI, M ;

HOSOI, Y ;

TOYA, T ;

KATAO, Y ;

MAEKAWA, K ;

KATSUMATA, S ;

YABUUCHI, K ;

ONOGI, T ;

SATOH, M .

NEUROSCIENCE LETTERS, 1993, 162 (1-2) :161-164

[20] CLONING AND EXPRESSION OF A CDNA FOR THE RAT KAPPA-OPIOID RECEPTOR [J].

MINAMI, M ;

TOYA, T ;

KATAO, Y ;

MAEKAWA, K ;

NAKAMURA, S ;

ONOGI, T ;

KANEKO, S ;

SATOH, M .

FEBS LETTERS, 1993, 329 (03) :291-295