Vesicular transport:: how many Ypt/Rab-GTPases make a eukaryotic cell?

被引：185

作者：

Lazar, T ^{[1
]}

Götte, M ^{[1
]}

Gallwitz, D ^{[1
]}

机构：

[1] Max Planck Inst Biophys Chem, Dept Mol Genet, D-37070 Gottingen, Germany

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1997年 / 22卷 / 12期

关键词：

D O I：

10.1016/S0968-0004(97)01150-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In eukaryotic cells, protein transport through the secretory and endocytic pathways is mediated by vesicular intermediates. Individual transport steps are regulated by Ras-like guanine nucleotide-binding proteins, termed Ypt in yeast or Rab in mammals. The complete sequencing of the Saccharomyces cerevisiae genome has revealed the total number of Ypt GTPases in this organism. There is some redundancy among the 11 Ypt proteins, and only those involved in the biosynthetic pathway are essential for cell viability.

引用

页码：468 / 472

页数：5

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