Decreased GLT-1 and increased SOD1 and HO-1 expression in astrocytes contribute to lumbar spinal cord vulnerability of SOD1-G93A transgenic mice

被引：24

作者：

Guo, Yansu ^{[1
,2
,3
]}

Duan, Weisong ^{[1
,2
,3
]}

Li, Zhongyao ^{[1
,2
,3
]}

Huang, Jing ^{[1
,2
,3
]}

Yin, Yunxia ^{[1
]}

Zhang, Kunxi ^{[1
]}

Wang, Qian ^{[1
]}

Zhang, Zhifang ^{[1
]}

Li, Chunyan ^{[1
,2
,3
]}

机构：

[1] Hebei Med Univ, Hosp 2, Dept Neurol, Shijiazhuang, Hebei Province, Peoples R China

[2] Hebei Med Univ, Hosp 2, Hebei Prov Key Lab Neurol, Shijiazhuang, Hebei Province, Peoples R China

[3] Inst Cardiocerebrovasc, Shijiazhuang, Hebei, Peoples R China

来源：

FEBS LETTERS | 2010年 / 584卷 / 08期

关键词：

ALS; Astrocyte; SOD1; Heme oxygenase-1; Transgenic mice; AMYOTROPHIC-LATERAL-SCLEROSIS; GLIAL GLUTAMATE TRANSPORTER; HEME OXYGENASE-1; ENDOTHELIAL-CELLS; DISEASE ONSET; MODEL; ALS; PROGRESSION; SUPEROXIDE; INJURY;

D O I：

10.1016/j.febslet.2010.03.025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The SOD1-G93A transgenic mouse is a widely used ALS model, but the death of lower motor neurons is the hallmark. Here, we show that the SOD1-G93A transgene and HO-1 are preferentially over-expressed in the lumbar spinal cord, particularly in the activated astrocytes of the transgenic mice. We also show down-regulation of GLT-1 in spite of the proliferating astrocytes. However, GLT-1, SOD1-G93A transgene and HO-1 expression were not obviously changed in the motor cortex. Our data link spinal cord vulnerability to relatively decreased expression of GLT-1, and high expression of the transgene and HO-1 in astrocytes in SOD1-G93A transgenic mice. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：1615 / 1622

页数：8

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