Application of lipases in kinetic resolution of racemates

被引：250

作者：

Ghanem, A

Aboul-Enein, HY

机构：

[1] King Faisal Specialist Hosp & Res Ctr, Pharmaceut Anal Lab, Dept Biol & Med Res, Riyadh 11211, Saudi Arabia

[2] Univ Geneva, Dept Organ Chem, CH-1211 Geneva 4, Switzerland

来源：

CHIRALITY | 2005年 / 17卷 / 01期

关键词：

biocatalysis; chiral separation; enantioselectivity; kinetic resolution; lipase;

D O I：

10.1002/chir.20089

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Lipases have been well established as valuable catalysts in organic synthesis. This review article focuses on some of the recent developments in the rapidly growing field of lipase-catalyzed kinetic resolution of racemates as a versatile method for the separation of enantiomers. The literature search dates back to the last five years and covers some comprehensive examples. The main emphasis is on the use of lipases in organic solvents. (C) 2004 Wiley-Liss, Inc.

引用

页码：1 / 15

页数：15

共 113 条

[1] Use of lipase-catalyzed kinetic resolution for the enantioselective approach toward sesquiterpenes containing quaternary centers: the cuparane family [J].