Genome sequence of the lignocellulose-bioconverting and xylose-fermenting yeast Pichia stipitis

被引：366

作者：

Jeffries, Thomas W.

Grigoriev, Igor V.

Grimwood, Jane

Laplaza, Jose M.

Aerts, Andrea

Salamov, Asaf

Schmutz, Jeremy

Lindquist, Erika

Dehal, Paramvir

Shapiro, Harris

Jin, Yong-Su

Passoth, Volkmar

Richardson, Paul M.

机构：

[1] US Forest Serv, Forest Prod Lab, USDA, Madison, WI 53705 USA

[2] Univ Wisconsin, Dept Bacteriol, Madison, WI 53706 USA

[3] DOE Joint Genome Inst, Walnut Creek, CA 94598 USA

[4] Stanford Univ, Human Genome Ctr, JGI Stanford, Palo Alto, CA 94304 USA

[5] Cargill, BioTechnol Dev Ctr, Minneapolis, MN 55440 USA

[6] Sungkyunkwan Univ, Dept Food Sci & Biotechnol, Suwon, South Korea

[7] Swedish Univ Agr Sci, Dept Microbiol, S-75007 Uppsala, Sweden

来源：

NATURE BIOTECHNOLOGY | 2007年 / 25卷 / 03期

关键词：

D O I：

10.1038/nbt1290

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 0836 [生物工程]; 090102 [作物遗传育种]; 100705 [微生物与生化药学];

摘要：

Xylose is a major constituent of plant lignocellulose, and its fermentation is important for the bioconversion of plant biomass to fuels and chemicals. Pichia stipitis is a well-studied, native xylose-fermenting yeast. The mechanism and regulation of xylose metabolism in P. stipitis have been characterized and genes from P. stipitis have been used to engineer xylose metabolism in Saccharomyces cerevisiae. We have sequenced and assembled the complete genome of P. stipitis. The sequence data have revealed unusual aspects of genome organization, numerous genes for bioconversion, a preliminary insight into regulation of central metabolic pathways and several examples of colocalized genes with related functions. The genome sequence provides insight into how P. stipitis regulates its redox balance while very efficiently fermenting xylose under microaerobic conditions.

引用

页码：319 / 326

页数：8

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