Reelin and brain development

被引：582

作者：

Tissir, F ^{[1
]}

Goffinet, AM ^{[1
]}

机构：

[1] Catholic Univ Louvain, Dev Genet Unit, B-1200 Brussels, Belgium

来源：

NATURE REVIEWS NEUROSCIENCE | 2003年 / 4卷 / 06期

关键词：

D O I：

10.1038/nrn1113

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Over the last 50 years, the reeler mutant mouse has become an important model for studying normal and abnormal development in the cerebral cortex and other regions of the brain. However, we are only just beginning to understand the actions of reelin - the protein that is affected by the reeler mutation - at the molecular and cellular level. This review discusses the most recent advances in this research field, and considers the merits of the various models that have been put forward to explain how reelin works.

引用

页码：496 / 505

页数：10

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