Mesenchymal Stem Cells on Horizon: A New Arsenal of Therapeutic Agents

被引：71

作者：

Abbasi-Malati, Zahra ^{[1
,2
]}

Roushandeh, Amaneh Mohammadi ^{[2
]}

Kuwahara, Yoshikazu ^{[3
]}

Roudkenar, Mehryar Habibi ^{[4
]}

机构：

[1] High Inst Res & Educ Transfus Med, Blood Transfus Res Ctr, Tehran, Iran

[2] Guilan Univ Med Sci, Paramed Fac, Med Biotechnol Res Ctr, Rasht, Iran

[3] Tohoku Med & Pharmaceut Univ, Div Radiat Biol & Med, Fac Med, Sendai, Miyagi, Japan

[4] Guilan Univ Med Sci, Cardiovasc Dis Res Ctr, Dept Cardiol, Heshmat Hosp,Sch Med, Rasht, Iran

来源：

STEM CELL REVIEWS AND REPORTS | 2018年 / 14卷 / 04期

关键词：

MSC; Secretome; Cell-free therapy; Condition medium; Therapeutic agents; REGULATORY DENDRITIC CELLS; MARROW STROMAL CELLS; VERSUS-HOST-DISEASE; CONDITIONED MEDIUM; IN-VITRO; BONE; EXOSOMES; SECRETOME; MICROVESICLES; PROTECT;

D O I：

10.1007/s12015-018-9817-x

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

Over 10 years, mesenchymal stem cells (MSCs) have been considered as valuable and suitable cells for cell-based therapy applications, particularly in clinical trials. In any case, they are as yet not utilized routinely in clinics. At first, it was believed that MSCs play their roles, especially in regenerative medicine due to their differentiation and cell replacement properties. Interestingly, it is well-known that MSCs mainly exert their therapeutic effects through their vast bioactive factors. These findings turned scientists' consideration toward cell-free therapy concepts. From this point of view, MSCs can be considered as an arsenal of natural bioreactors in variety of therapeutic agents. MSCs inherently express various important therapeutic agents such as growth factors and cytokines that can be manufactured, handled and stored as a prepared-to-go biologic product. In this review, we provide a vision, highlight as well as discuss in order to introduce competitive natural robust bioreactor MSCs on the horizon.

引用

页码：484 / 499

页数：16

共 142 条

[21]

Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-κB signaling in resident macrophages [J].