CD1-restricted antigen presentation: an oily matter

被引：25

作者：

Joyce, S ^{[1
]}

Van Kaer, L ^{[1
]}

机构：

[1] Vanderbilt Univ, Dept Microbiol & Immunol, Sch Med, Nashville, TN 37232 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2003年 / 15卷 / 01期

关键词：

D O I：

10.1016/S0952-7915(02)00012-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD1 molecules control diverse immune functions by presenting self and non-self lipid antigens to T lymphocytes. The recent solution of the human CD1 b structure has revealed the first principles for the structural basis of the presentation of unique and overlapping sets of lipids. Additionally, new studies have shed light on the unique aspects of intracellular CD1 traffic, lipid antigen processing and T cell recognition of non-peptidlic ligands.

引用

收藏

页码：95 / 104

页数：10

相关论文

共 65 条

[1] ISOLATION AND CHARACTERIZATION OF A CDNA AND GENE CODING FOR A 4TH CD1 MOLECULE [J].

BALK, SP ;

BLEICHER, PA ;

TERHORST, C .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (01) :252-256

[2] RECOGNITION OF A LIPID ANTIGEN BY CD1-RESTRICTED ALPHA-BETA(+) T-CELLS [J].

BEEKMAN, EM ;

PORCELLI, SA ;

MORITA, CT ;

BEHAR, SM ;

FURLONG, ST ;

BRENNER, MB .

NATURE, 1994, 372 (6507) :691-694

[3]

Besra Gurdyal S., 1994, P285

[4] THE IDENTIFICATION OF THE BETA-2-MICROGLOBULIN BINDING ANTIGEN ENCODED BY THE HUMAN CD1D GENE [J].

BILSLAND, CAG ;

MILSTEIN, C .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1991, 21 (01) :71-78

[5] MOUSE CD1 IS DISTINCT FROM AND COEXISTS WITH TL IN THE SAME THYMUS [J].

BRADBURY, A ;

BELT, KT ;

NERI, TM ;

MILSTEIN, C ;

CALABI, F .

EMBO JOURNAL, 1988, 7 (10) :3081-3086

[6] Human CD1b and CD1c isoforms survey different intracellular compartments for the presentation of microbial lipid antigens [J].

Briken, V ;

Jackman, RM ;

Watts, GFM ;

Rogers, RA ;

Porcelli, SA .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (02) :281-287

[7] Intracellular trafficking pathway of newly synthesized CD1b molecules [J].

Briken, V ;

Jackman, RM ;

Dasgupta, S ;

Hoening, S ;

Porcelli, SA .

EMBO JOURNAL, 2002, 21 (04) :825-834

[8]

Brossay L, 1998, J IMMUNOL, V161, P5124

[9] 2 CLASSES OF CD1 GENES [J].

CALABI, F ;

JARVIS, JM ;

MARTIN, L ;

MILSTEIN, C .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1989, 19 (02) :285-292

[10] THE RABBIT CD1 AND THE EVOLUTIONARY CONSERVATION OF THE CD1 GENE FAMILY [J].

CALABI, F ;

BELT, KT ;

YU, CY ;

BRADBURY, A ;

MANDY, WJ ;

MILSTEIN, C .

IMMUNOGENETICS, 1989, 30 (05) :370-377

← 1 2 3 4 5 6 7 →