The primary cilium: a signalling centre during vertebrate development

被引：1381

作者：

Goetz, Sarah C. ^{[1
]}

Anderson, Kathryn V. ^{[1
]}

机构：

[1] Sloan Kettering Inst, Dev Biol Program, New York, NY 10065 USA

来源：

NATURE REVIEWS GENETICS | 2010年 / 11卷 / 05期

基金：

美国国家卫生研究院;

关键词：

PLANAR CELL POLARITY; LEFT-RIGHT ASYMMETRY; KINESIN-LIKE PROTEIN; BASAL BODY PROTEOME; E3 UBIQUITIN LIGASE; INTRAFLAGELLAR TRANSPORT; SONIC HEDGEHOG; CENTROSOMAL PROTEIN; REPRESSOR FUNCTIONS; TALPID3; MUTANT;

D O I：

10.1038/nrg2774

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The primary cilium has recently stepped into the spotlight, as a flood of data show that this organelle has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialized for hedgehog signal transduction. The formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The cilium therefore represents a nexus for signalling pathways during development. The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction.

引用

页码：331 / 344

页数：14

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