RNA-binding proteins and mRNA turnover in trypanosomes

被引：50

作者：

D'Orso, I ^{[1
]}

De Gaudenzi, JG ^{[1
]}

Frasch, ACC ^{[1
]}

机构：

[1] UNSAM, CONICET, Inst Invest Biotecnol,INTI, Inst Tecnol Chascomus, RA-1650 Buenos Aires, DF, Argentina

来源：

TRENDS IN PARASITOLOGY | 2003年 / 19卷 / 04期

关键词：

D O I：

10.1016/S1471-4922(03)00035-7

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Trypanosomes, protozoan parasites of the order Kinetoplastida, control gene expression essentially through post-transcriptional mechanisms. Several motifs located mainly in the 3' untranslated region, such as AU-rich elements (AREs), were recently shown to modulate mRNA half-life, and are able to modify mRNA abundance in vivo through the interaction with specific RNA-binding proteins. Along with the detection of an active exosome, decapping activities and a regulated 3' to 5' exonuclease activity stimulated by AREs, these results suggest that modulation of mRNA stability is essential in trypanosomes. These regulatory processes are specific for different developmental stages and thus relevant for allowing trypanosomes to adapt to variable environmental conditions.

引用

收藏

页码：151 / 155

页数：5

相关论文

共 36 条

[21] PARP gene expression: control at many levels [J].

Hotz, HR ;

Biebinger, S ;

Flaspohler, J ;

Clayton, C .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1998, 91 (01) :131-143

[22] Degradation of the unstable EP1 mRNA in Trypanosoma brucei involves initial destruction of the 3′-untranslated region [J].

Irmer, H ;

Clayton, C .

NUCLEIC ACIDS RESEARCH, 2001, 29 (22) :4707-4715

[23] Characterization of a SR protein from Trypanosoma brucei with homology to RNA-binding cis-splicing proteins [J].

Ismaïli, N ;

Pérez-Morga, D ;

Walsh, P ;

Mayeda, A ;

Pays, A ;

Tebabi, P ;

Krainer, AR ;

Pays, E .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1999, 102 (01) :103-115

[24] Characterization of a Trypanosoma brucei SR domain-containing protein bearing homology to cis-spliceosomal U1 70 kDa proteins [J].

Ismaïli, N ;

Pérez-Morga, D ;

Walsh, P ;

Cadogan, M ;

Pays, A ;

Tebabi, P ;

Pays, E .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 2000, 106 (01) :109-120

[25] Translational repression by a novel partner of human poly(A) binding protein, Paip2 [J].

Khaleghpour, K ;

Svitkin, YV ;

Craig, AW ;

DeMaria, CT ;

Deo, RC ;

Burley, SK ;

Sonenberg, N .

MOLECULAR CELL, 2001, 7 (01) :205-216

[26] Transport into and out of the nucleus [J].

Macara, IG .

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 2001, 65 (04) :570-+

[27] A new twist in trypanosome RNA metabolism:: cis-splicing of pre-mRNA [J].

Mair, G ;

Shi, HF ;

Li, HJ ;

Djikeng, A ;

Aviles, HO ;

Bishop, JR ;

Falcone, FH ;

Gavrilescu, C ;

Montgomery, JL ;

Santori, MI ;

Stern, LS ;

Wang, ZF ;

Ullu, E ;

Tschudi, C .

RNA, 2000, 6 (02) :163-169

[28] A COMMON PYRIMIDINE-RICH MOTIF GOVERNS TRANSSPLICING AND POLYADENYLATION OF TUBULIN POLYCISTRONIC PRE-MESSENGER-RNA IN TRYPANOSOMES [J].

MATTHEWS, KR ;

TSCHUDI, C ;

ULLU, E .

GENES & DEVELOPMENT, 1994, 8 (04) :491-501

[29] Identification of mRNA decapping activities and an ARE-regulated 3′ to 5′ exonuclease activity in trypanosome extracts [J].

Milone, J ;

Wilusz, J ;

Bellofatto, V .

NUCLEIC ACIDS RESEARCH, 2002, 30 (18) :4040-4050

[30] A unified theory of gene expression [J].

Orphanides, G ;

Reinberg, D .

CELL, 2002, 108 (04) :439-451

← 1 2 3 4 →