Reductive alkylation of thioureas:: a highly practical synthesis of unsymmetrical N,N′-disubstituted thioureas

被引：24

作者：

Ciszewski, L ^{[1
]}

Xu, DQ ^{[1
]}

Repic, J ^{[1
]}

Blacklock, TJ ^{[1
]}

机构：

[1] Proc R&D, Chem & Analyt Dev, Novartis Inst Biomed Res, E Hanover, NJ 07936 USA

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 43期

关键词：

D O I：

10.1016/j.tetlet.2004.08.182

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

A highly practical synthesis of unsymmetrical N,N'-disubstituted thioureas by the reductive alkylation of N-monosubstituted thioureas with aldehydes is described. N-Monosubstituted thioureas can in turn be synthesized by the reductive amination of thiourea with an appropriate aldehyde. This reductive alkylation methodology was also extended to carbamates. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：8091 / 8093

页数：3

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