Reductive alkylation of urea: A practical route to substituted ureas

被引：22

作者：

Xu, DQ ^{[1
]}

Ciszewski, L ^{[1
]}

Li, TQ ^{[1
]}

Repic, O ^{[1
]}

Blacklock, TJ ^{[1
]}

机构：

[1] Novartis Pharmaceut Corp, Chem & Anal Dev, Proc Res & Dev, E Hanover, NJ 07936 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 10期

关键词：

D O I：

10.1016/S0040-4039(97)10816-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Conditions are disclosed for the formation of either mono-or di-substituted ureas by reductive alkylation, which are readily adaptable to large scale preparations. Dehydrating agents such as acetyl chloride or trimethylsilyl chloride effectively promote the condensation of ureas and aldehydes. Reduction of the adducts affords the mono-or di-substituted ureas in high yields. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1107 / 1110

页数：4

共 12 条

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