Functionalized carbon nanotubes for plasmid DNA gene delivery

被引：732

作者：

Pantarotto, D

Singh, R

McCarthy, D

Erhardt, M

Briand, JP

Prato, M ^{[1
]}

Kostarelos, K

Bianco, A

机构：

[1] Univ Trieste, Dipartimento Sci Farmaceut, I-34127 Trieste, Italy

[2] Univ London, Sch Pharm, Electron Microscopy Unit, London WC1N 1AX, England

[3] Univ London, Sch Pharm, Ctr Drug Delivery Res, London WC1N 1AX, England

[4] CNRS, UPR9021, Inst Biol Mol & Cellulaire, F-67084 Strasbourg, France

[5] Inst Biol Mol Plantes, F-67084 Strasbourg, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 39期

关键词：

carbon nanotubes; gene delivery; plasmid DNA; supramolecular chemistry;

D O I：

10.1002/anie.200460437

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Genetic vaccination and gene therapy research could benefit from the application of carbon nanotubes. Functionalized, positively charged, water-soluble carbon nanotubes are able to penetrate into cells (see figure) and can transport plasmid DNA by formation of noncovalent DNA-nanotube complexes. Such nanotubes can be used as novel nonviral delivery systems for gene transfer.

引用

页码：5242 / 5246

页数：5

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