Uridine and pyruvate protect T cells' proliferative capacity from mitochondrial toxic antibiotics: a clinical pilot study

被引：16

作者：

Battaglia, Stefano ^{[1
,2
]}

De Santis, Stefania ^{[1
,3
]}

Rutigliano, Monica ^{[2
]}

Sallustio, Fabio ^{[1
]}

Picerno, Angela ^{[2
]}

Frassanito, Maria Antonia ^{[4
]}

Schaefer, Ingo ^{[5
]}

Vacca, Angelo ^{[4
]}

Moschetta, Antonio ^{[1
]}

Seibel, Peter ^{[5
]}

Battaglia, Michele ^{[2
]}

Villani, Gaetano ^{[6
]}

机构：

[1] Aldo Moro Univ Bari, Dept Interdisciplinary Med, I-70124 Bari, Italy

[2] Aldo Moro Univ Bari, Dept Emergency & Organ Transplants, I-70124 Bari, Italy

[3] Aldo Moro Univ Bari, Dept Pharm Drug Sci, I-70126 Bari, Italy

[4] Aldo Moro Univ Bari, Dept Biomed Sci & Human Oncol, I-70124 Bari, Italy

[5] Univ Leipzig, Med Fac, BBZ, Mol Cell Therapy, D-04103 Leipzig, Germany

[6] Aldo Moro Univ Bari, Dept Basic Med Sci Neurosci & Sense Organs, I-70124 Bari, Italy

来源：

SCIENTIFIC REPORTS | 2021年 / 11卷 / 01期

关键词：

IMMUNE; RESISTANCE;

D O I：

10.1038/s41598-021-91559-8

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Antibiotics that inhibit bacterial protein or nucleic acid synthesis and function can exert an off-target action on mitochondria (mitotoxic antibiotics), making actively dividing mammalian cells dependent on uridine and pyruvate supplementation. Based on this rationale, we carried out, for the first time, a randomized pilot study in 55 patients with asymptomatic bacteriuria or positive sperm culture, each treated with a single mitotoxic antibiotic with or without oral supplementation of uridine+pyruvate (Uripyr, Mitobiotix, Italy). The in vivo and ex vivo data show a a 3.4-fold higher value in the differential (before and after the antibiotic treatment) lymphocytes count and a 3.7-fold increase in the percentage of dividing T cells, respectively, in the Uripyr vs the control group. Our findings lay the groundwork to enhance the synergy between antibiotics and the immune system in order to optimize the administration protocols and widen the application potentials of antibiotic therapies as well as to re-evaluate old "forgotten" molecules to fight bacterial infections in the antibiotics resistance era.

引用

页数：9

共 38 条

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