A collaborative database of inbred mouse strain characteristics

被引：71

作者：

Grubb, SC ^{[1
]}

Churchill, GA ^{[1
]}

Bogue, MA ^{[1
]}

机构：

[1] Jackson Lab, Bar Harbor, ME 04609 USA

来源：

BIOINFORMATICS | 2004年 / 20卷 / 16期

关键词：

D O I：

10.1093/bioinformatics/bth299

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A database and website (MPD: Mouse Phenome Database) have been developed to serve as a consolidated home for mouse strain characterization data being generated by the scientific community. Physiological, anatomical and behavioral data are being collected and integrated into a common framework for tabulation by strain and sex. Genotypic data are being collected as well. The current focus is on a set of 40 inbred strains. The MPD as of February 2004 contains approximately 500 phenotypic parameters relevant to human health, voluntarily contributed by several dozen investigators and laboratories.

引用

收藏

页码：2857 / 2859

页数：3

相关论文

共 10 条

[1] Genealogies of mouse inbred strains [J].

Beck, JA ;

Lloyd, S ;

Hafezparast, M ;

Lennon-Pierce, M ;

Eppig, JT ;

Festing, MFW ;

Fisher, EMC .

NATURE GENETICS, 2000, 24 (01) :23-+

[2] Anxiety-related behaviors in the elevated zero-maze are affected by genetic factors and retinal degeneration [J].

Cook, MN ;

Williams, RW ;

Flaherty, L .

BEHAVIORAL NEUROSCIENCE, 2001, 115 (02) :468-476

[3]

Festing M. F. W., 1997, Mouse Genome, V95, P519

[4] Sex and strain-related differences in the peripheral blood cell values of inbred mouse strains [J].

Kile, BT ;

Mason-Garrison, CL ;

Justice, MJ .

MAMMALIAN GENOME, 2003, 14 (01) :81-85

[5] A mouse phenome project [J].

Paigen, K ;

Eppig, JT .

MAMMALIAN GENOME, 2000, 11 (09) :715-717

[6] Large-scale, high-throughput screening for coagulation and hematologic phenotypes in mice [J].

Peters, LL ;

Cheever, EM ;

Ellis, HR ;

Magnani, PA ;

Svenson, KL ;

Von Smith, R ;

Bogue, MA .

PHYSIOLOGICAL GENOMICS, 2002, 11 (03) :185-193

[7] dbSNP: the NCBI database of genetic variation [J].

Sherry, ST ;

Ward, MH ;

Kholodov, M ;

Baker, J ;

Phan, L ;

Smigielski, EM ;

Sirotkin, K .

NUCLEIC ACIDS RESEARCH, 2001, 29 (01) :308-311

[8] The mosaic structure of variation in the laboratory mouse genome [J].

Wade, CM ;

Kulbokas, EJ ;

Kirby, AW ;

Zody, MC ;

Mullikin, JC ;

Lander, ES ;

Lindblad-Toh, K ;

Daly, MJ .

NATURE, 2002, 420 (6915) :574-578

[9]

WILLOTT JF, 2003, BEHAV NEUROSCI, V4, P16

[10] Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse [J].

Wiltshire, T ;

Pletcher, MT ;

Batalov, S ;

Barnes, SW ;

Tarantino, LM ;

Cooke, MP ;

Wu, H ;

Smylie, K ;

Santrosyan, A ;

Copeland, NG ;

Jenkins, NA ;

Kalush, F ;

Mural, RJ ;

Glynne, RJ ;

Kay, SA ;

Adams, MD ;

Fletcher, CF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (06) :3380-3385