Genetics of stroke - a review

被引：28

作者：

Rastenyte, D ^{[1
]}

Tuomilehto, J ^{[1
]}

Sarti, C ^{[1
]}

机构：

[1] Natl Publ Hlth Inst, Dept Epidemiol & Hlth Promot, FIN-00300 Helsinki, Finland

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1998年 / 153卷 / 02期

关键词：

stroke; genetics;

D O I：

10.1016/S0022-510X(97)00286-4

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Evidence from twin and family shows that genetic factors contribute to the risk of stroke and that their role may be at least as important in stroke as in coronary heart disease. Additional support for the significance of genetic factors comes from other findings such as epidemiological data showing phenotypic heterogeneity of stroke, genetic influence on many of the risk factors for stroke, and racial and geographic differences in morbidity and mortality in stroke victims. Yet, apart from the reported associations of a small number of cases with Mendelian cerebrovascular diseases, only a few studies have directly investigated gene markers or molecular genetics of stroke. This review presents the existing evidence on the genetic background of stroke and discusses results from the genetic studies of stroke published to date. (C) 1998 Elsevier Science.

引用

页码：132 / 145

页数：14

共 181 条

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