Genetic pathways to colorectal cancer

被引：12

作者：

Boland, CR

机构：

[1] University of California, San Diego, CA

[2] Division of Gastroenterology, Department of Medicine, University of California, San Diego, CA

来源：

HOSPITAL PRACTICE | 1997年 / 32卷 / 11期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1080/21548331.1997.11443598

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The first known cancer family would be described today as having hereditary nonpolyposis colorectal cancer, in which, as in familial adenomatous polyposis, the emergence of a malignancy requires a seemingly unlikely sequence of somatic mutations, superimposed on a risk-conveying inheritance. Events identified in the inherited syndromes are proving crucial in learning precisely how nonfamilial tumors develop.

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页码：79 / &

页数：15

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