Pfam: multiple sequence alignments and HMM-profiles of protein domains

被引：551

作者：

Sonnhammer, ELL

Eddy, SR

Birney, E

Bateman, A

Durbin, R

机构：

[1] Natl Lib Med, Natl Ctr Biotechnol Informat, Computat Biol Branch, Bethesda, MD 20894 USA

[2] Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA

[3] Sanger Ctr, Cambridge CB10 1SA, England

来源：

NUCLEIC ACIDS RESEARCH | 1998年 / 26卷 / 01期

基金：

英国惠康基金;

关键词：

D O I：

10.1093/nar/26.1.320

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pfam contains multiple alignments and hidden Markov model based profiles (HMM-profiles) of complete protein domains. The definition of domain boundaries, family members and alignment is done semi-automatically based on expert knowledge, sequence similarity, other protein family databases and the ability of HMM-profiles to correctly identify and align the members, Release 2.0 of Pfam contains 527 manually verified families which are available for browsing and on-line searching via the World Wide Web in the UK at http://www.sanger.ac.uk/Pfam/ and in the US at http://genome.wustl.edu/Pfam/Pfam 2.0 matches one or more domains in 50% of Swissprot-34 sequences, and 25% of a large sample of predicted proteins from the Caenorhabditis elegans genome.

引用

页码：320 / 322

页数：3