Radical (phenylsulfonyl)difluoromethylation with iododifluoromethyl phenyl sulfone

被引：60

作者：

Li, Ya ^{[1
]}

Liu, Jun ^{[1
]}

Zhang, Laijun ^{[1
]}

Zhu, Lingui ^{[1
]}

Hu, Jinbo ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2007年 / 72卷 / 15期

关键词：

NUCLEOPHILIC DIFLUOROMETHYLATION; CARBONYL-COMPOUNDS; ALPHA; ALPHA-DIFLUORO-FUNCTIONALIZED ESTERS; STEREOSELECTIVE-SYNTHESIS; EQUIVALENT; ALCOHOLS; ROUTE; AMINES;

D O I：

10.1021/jo070618s

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An unprecedented radical (phenylsulfonyl)difluoromethylation of terminal alkenes with PhSO2CF2I has been achieved by using Et3B/air as an initiator. This synthetic methodology was also used in the one-pot regioselective preparation of PhSO2CF2-substituted alkanes, and in the regio- and stereoselective preparation of PhSO2CF2-substituted alkenes with high E/Z ratio (up to >= 100:1).

引用

页码：5824 / 5827

页数：4

共 37 条

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