Live Attenuated Influenza Vaccine

被引：57

作者：

Jin, Hong ^{[1
]}

Subbarao, Kanta ^{[2
]}

机构：

[1] MedImmune LLC, Mountain View, CA 94043 USA

[2] NIAID, Infect Dis Lab, NIH, Bethesda, MD 20892 USA

来源：

INFLUENZA PATHOGENESIS AND CONTROL - VOL II | 2015年 / 386卷

关键词：

ANN-ARBOR STRAIN; CELLULAR IMMUNE-RESPONSES; CULTURE-CONFIRMED INFLUENZA; MASTER DONOR VIRUS; POSTMARKETING EVALUATION; TEMPERATURE SENSITIVITY; GENOTYPIC STABILITY; B VIRUS; EFFICACY; SAFETY;

D O I：

10.1007/82_2014_410

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cold-adapted Ann Arbor based live attenuated influenza vaccine (LAIV) has been available in the USA since 2003. The vaccine is efficacious against influenza infection. Features of LAIV include: easy administration suitable for mass immunization, cross-reactivity to drifted strains for broader coverage, and establishment of herd immunity for control of influenza spread. Annual seasonal LAIV now contains four strains against influenza A H1N1, H3N2, influenza B-Victoria, and B-Yamagata lineages that are co-circulating in humans. LAIV played a significant role in protecting the public from the 2009 H1N1 pandemic and has been evaluated for pandemic preparedness. Pandemic vaccines including influenza H2, H5, H6, H7, and H9 subtypes have been produced and evaluated in preclinical and small-scale phase I clinical studies. This review summarizes the current status and perspectives of seasonal and pandemic LAIV.

引用

收藏

页码：181 / 204

页数：24

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