Small GTP binding proteins and bacterial virulence

Many bacterial toxins and bacterial enzymes modify small GTPases. Toxins exhibit different enzymatic activities on either the switch 1 or switch 2 domains of these small GTPases leading to inactivation or activation of such intracellular timer molecules. In addition, some virulence factors of certain invasive bacteria such as Salmonella also modulate small GTP binding proteins either by mimicking GTPase exchange factors or GTPase activating proteins. (C) 2000 Editions scientifiques er medicales Elsevier SAS.