A concise synthesis of protected diethyl 1-amino-2-hydroxyalkylphosphonates

被引：15

作者：

Blazewska, K ^{[1
]}

Sikora, D ^{[1
]}

Gajda, T ^{[1
]}

机构：

[1] Lodz Tech Univ Politechnika, Inst Organ & Macromol Chem, PL-90924 Lodz, Poland

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 25期

关键词：

oxazolidine-2-thiones; oxazolidin-2-one; diethyl; 1-amino-2-hydroxyalkylphosphonates;

D O I：

10.1016/S0040-4039(03)01048-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient diastereoselective synthesis of 5-substituted (2-thioxo-oxazolidin-4-yl)phosphonic acid diethyl esters from metallated diethyl isothiocyanomethylphosphonate and aldehydes has been developed. The three-step transformation of oxazolidine-2-thione derivatives into N-Boc 1-amino-2-hydroxyalkylphosphonic acid diethyl esters is also described. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：4747 / 4750

页数：4

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