Cardiovascular endocrinology 1 - Aldosterone function in diabetes mellitus: Effects on cardiovascular and renal disease

被引：49

作者：

McFarlane, SI

Sowers, JR

机构：

[1] SUNY Hlth Sci Ctr, Endocrinol Diabet & Hypertens Div, Dept Med, Brooklyn, NY 11203 USA

[2] SUNY Hlth Sci Ctr, Endocrinol Diabet & Hypertens Div, Dept Cell Biol, Brooklyn, NY 11203 USA

[3] Kings Cty Hosp Ctr, Brooklyn, NY 11203 USA

[4] Vet Affairs Med Ctr, Brooklyn, NY 11203 USA

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 2003年 / 88卷 / 02期

关键词：

PLASMINOGEN-ACTIVATOR INHIBITOR-1; HEALTH-CARE PROFESSIONALS; IMPAIRED FASTING GLUCOSE; HEART-RATE-VARIABILITY; RISK-FACTORS; INSULIN-RESISTANCE; INDUCED HYPERTROPHY; FOLLOW-UP; HYPERTENSION; STROKE;

D O I：

10.1210/jc.2002-021443

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There is accumulating evidence for the role of aldosterone as a risk factor for cardiovascular and renal disease in type 2 diabetes, above and beyond that of Ang II. Preliminary evidence suggests favorable cardiovascular and renal effects of blocking aldosterone actions. Further studies are needed to assess the potential benefits of a combination of ACE/ARB and aldosterone antagonists in reducing the burden of CVD and renal disease in such a high-risk patient population.

引用

页码：516 / 523

页数：8

共 67 条

[1] Role of 11β-hydroxysteroid dehydrogenase in nongenomic aldosterone effects in human arteries [J].