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Cardiovascular endocrinology 1 - Aldosterone function in diabetes mellitus: Effects on cardiovascular and renal disease

被引：49
作者：
McFarlane, SI
Sowers, JR
机构：
[1] SUNY Hlth Sci Ctr, Endocrinol Diabet & Hypertens Div, Dept Med, Brooklyn, NY 11203 USA
[2] SUNY Hlth Sci Ctr, Endocrinol Diabet & Hypertens Div, Dept Cell Biol, Brooklyn, NY 11203 USA
[3] Kings Cty Hosp Ctr, Brooklyn, NY 11203 USA
[4] Vet Affairs Med Ctr, Brooklyn, NY 11203 USA
来源：
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 2003年 / 88卷 / 02期
关键词：
PLASMINOGEN-ACTIVATOR INHIBITOR-1; HEALTH-CARE PROFESSIONALS; IMPAIRED FASTING GLUCOSE; HEART-RATE-VARIABILITY; RISK-FACTORS; INSULIN-RESISTANCE; INDUCED HYPERTROPHY; FOLLOW-UP; HYPERTENSION; STROKE;
D O I：
10.1210/jc.2002-021443
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
There is accumulating evidence for the role of aldosterone as a risk factor for cardiovascular and renal disease in type 2 diabetes, above and beyond that of Ang II. Preliminary evidence suggests favorable cardiovascular and renal effects of blocking aldosterone actions. Further studies are needed to assess the potential benefits of a combination of ACE/ARB and aldosterone antagonists in reducing the burden of CVD and renal disease in such a high-risk patient population.
引用
收藏
页码：516 / 523
页数：8
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