Fluvoxamine suppresses the long-term potentiation in the hippocampal CAl field of anesthetized rats:: an effect mediated via 5-HT1A receptors

被引：47

作者：

Kojima, T

Matsumoto, M ^{[1
]}

Togashi, H

Tachibana, K

Kemmotsu, O

Yoshioka, M

机构：

[1] Hokkaido Univ, Sch Med, Dept Pharmacol, Sapporo, Hokkaido 0608638, Japan

[2] Hokkaido Univ, Sch Med, Dept Anesthesiol Crit Care Med, Sapporo, Hokkaido 0608638, Japan

来源：

BRAIN RESEARCH | 2003年 / 959卷 / 01期

关键词：

fluvoxamine; 5-HT1A receptor; synaptic plasticity; long-term potentiation; hippocampal CA1 field;

D O I：

10.1016/S0006-8993(02)03756-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A selective 5-HT reuptake inhibitor, fluvoxamine (10 and 30 mg/kg, i.p.) suppressed long-term potentiation (LTP) in the hippocampal CA1 field of anesthetized rats. Fluvoxamine (30 mg/kg, i.p.)-induced suppression of LTP was completely reversed by the 5-HT A receptor antagonist NAN-190 (0.5 mg/kg, i.p), but not by the 5-HT4 receptor antagonist GR 113808 (20 l.Lg/rat, i.c.v.) and the 5-HT7 receptor antagonist DR 4004 (10 mug/rat, i.c.v.). These data suggest that the inhibitory effect of fluvoxamine on LTP induction is mediated via 5-HT1A receptors. (C) 2002 Elsevier Science B.V. All rights reserved.

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页码：165 / 168

页数：4

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