Tetrahydrobenzindoles:: Selective antagonists of the 5-HT7 receptor

被引：116

作者：

Kikuchi, C ^{[1
]}

Nagaso, H ^{[1
]}

Hiranuma, T ^{[1
]}

Koyama, M ^{[1
]}

机构：

[1] Meiji Seika Kaisha Ltd, Pharmaceut Res Ctr, Kohoku Ku, Yokohama, Kanagawa 2228567, Japan

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1999年 / 42卷 / 04期

关键词：

D O I：

10.1021/jm980519u

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：533 / 535

页数：3

共 23 条

[1]

BARD JA, 1993, J BIOL CHEM, V268, P23422

[2]

Branchek T. A., 1994, British Journal of Pharmacology, V112, p100P

[3]

Cushing DJ, 1996, J PHARMACOL EXP THER, V277, P1560

[4] (R)-3,N-dimethyl-N-[1-methyl-3-(4-methyl-piperidin-1-yl)propyl]benzenesulfonamide:: The first selective 5-HT7 receptor antagonist [J].

Forbes, IT ;

Dabbs, S ;

Duckworth, DM ;

Jennings, AJ ;

King, FD ;

Lovell, PJ ;

Brown, AM ;

Collin, L ;

Hagan, JJ ;

Middlemiss, DN ;

Riley, GJ ;

Thomas, DR ;

Upton, N .

JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (05) :655-657

[5] A receptor autoradiographic and in situ hybridization analysis of the distribution of the 5-ht(7) receptor in rat brain [J].

Gustafson, EL ;

Durkin, MM ;

Bard, JA ;

Zgombick, J ;

Branchek, TA .

BRITISH JOURNAL OF PHARMACOLOGY, 1996, 117 (04) :657-666

[6]

Heidmann DEA, 1997, J NEUROCHEM, V68, P1372

[7] Cloning, expression and pharmacology of a truncated splice variant of the human 5-HT7 receptor (h5-HT7(b)) [J].

Jasper, JR ;

Kosaka, A ;

To, ZP ;

Chang, DJ ;

Eglen, RM .

BRITISH JOURNAL OF PHARMACOLOGY, 1997, 122 (01) :126-132

[8] Characterization of putative 5-ht(7) receptors mediating direct relaxation in Cynomolgus monkey isolated jugular vein [J].

Leung, E ;

Walsh, LKM ;

PulidoRios, MT ;

Eglen, RM .

BRITISH JOURNAL OF PHARMACOLOGY, 1996, 117 (05) :926-930

[9] A NOVEL ADENYLYL CYCLASE-ACTIVATING SEROTONIN RECEPTOR (5-HT7) IMPLICATED IN THE REGULATION OF MAMMALIAN CIRCADIAN-RHYTHMS [J].

LOVENBERG, TW ;

BARON, BM ;

DELECEA, L ;

MILLER, JD ;

PROSSER, RA ;

REA, MA ;

FOYE, PE ;

RACKE, M ;

SLONE, AL ;

SIEGEL, BW ;

DANIELSON, PE ;

SUTCLIFFE, JG ;

ERLANDER, MG .

NEURON, 1993, 11 (03) :449-458

[10]

MARTIN GR, 1995, BRIT J PHARMACOL, V114, pP383

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